Results 41 to 50 of about 7,438 (306)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The effect of cessation of drinking water fluoridation on dental restorations and crowns in children aged 3–5 years in Israel – a retrospective study

Israel Journal of Health Policy Research
Background Community water fluoridation began in the 1945 as a public health measure to prevent and control caries and was implemented in Israel in 1981.
Shiran Shemesh Nezihovski, Mordechai Findler, Tali Chackartchi, Jonathan Mann, Doron Haim, Guy Tobias   +5 more
doaj   +1 more source

The costs and benefits of water fluoridation in NZ

BMC Oral Health, 2017
Background Implementing community water fluoridation involves costs, but these need to be considered against the likely benefits. We aimed to assess the cost-benefit and cost-effectiveness of water fluoridation in New Zealand (NZ) in terms of expenditure
David Moore, Matthew Poynton, Jonathan M. Broadbent, W. Murray Thomson   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Bioethical considerations about water fluoridation: a critical review.

Journal of Oral Research, 2016
Dental caries is one of the oral pathologies with greater burden of disease in the Chilean population. Fluoridation of drinking water has been used as a caries prevention strategy. However, its application as a public policy has been questioned since its
María Elisa Quinteros
doaj   +1 more source

Cost-Benefit Analysis of Drinking Water Fluoridation in 12-year-old Children in the Biobío Region, Chile.

Journal of Oral Research, 2021
Fluoridation has been shown to be an effective measure against caries in children. The present study evaluates the cost-benefit of the fluoridated water program for the reduction of dental caries in 12-year-old children in the Biobío Region, the only ...
Camilo Ulloa, Catherine de la Puente, Fernando Rojas, Sofía Irigoyen, Raúl Flores-Cartes   +4 more
doaj   +1 more source

The Fluoride Debate: The Pros and Cons of Fluoridation [PDF]

Preventive Nutrition and Food Science, 2018
Fluoride is one of the most abundant elements found in nature. Water is the major dietary source of fluoride. The only known association with low fluoride intake is the risk of dental caries. Initially, fluoride was considered beneficial when given systemically during tooth development, but later research has shown the importance and the advantages of ...
Aoun, Antoine, Darwiche, Farah, Al Hayek, Sibelle, Doumit, Jacqueline   +3 more
openaire   +2 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Community Water Fluoridation a Cost–Benefit–Risk Consideration

Public Health Challenges
For over 70 years, the addition of fluoride to public water as community water fluoridation (CWF or fluoridation) with intent to prevent dental caries continues to be controversial, and risks are seldom included in monetary evaluations.
Bill Osmunson, Griffin Cole
doaj   +1 more source