Results 41 to 50 of about 374,416 (293)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Concentration of Fluoride in Cow’s and Buffalo’s Milk in Relation to Varying Levels of Fluoride Concentration in Drinking Water of Mathura City in India– A Pilot Study [PDF]

Journal of Clinical and Diagnostic Research, 2015
Aim: To estimate fluoride concentration in drinking water, cow’s milk and buffalo’s milk and to correlate the concentration of fluoride in cow’s milk and buffalo’s milk with varying levels of fluoride concentration in drinking water.
Prahlad Gupta, Nidhi Gupta, Komal Meena, Ninad Joshirao Moon, Puneet Kumar, Ravneet Kaur   +5 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Fluoride retention in saliva and in dental biofilm after different home-use fluoride treatments

Brazilian Oral Research, 2014
This single-blind, randomized, crossover study aimed at assessing the long-term fluoride concentrations in saliva and in dental biofilm after different home-use fluoride treatments. The study volunteers (n = 38) were residents of an area with fluoridated
Daniela Correia Cavalcante SOUZA, Marisa MALTZ, Lina Naomi HASHIZUME   +2 more
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Assessment of fluoride bio-accessibility in early childhood diets

Frontiers in Oral Health
IntroductionCurrently available dietary recommendations for fluoride provided as “adequate intake” (AI) and “tolerable upper intake level” (UL) assume 100% fluoride availability for utilization by the body, which is often not the case.
Jelena Kronic, Ralph M. Duckworth, Claudio Angione, Steven M. Levy, Fatemeh Vida Zohoori   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Fluoride resistance in Streptococcus mutans: a mini review

Journal of Oral Microbiology, 2017
For decades, fluoride has been used extensively as an anti-caries agent. It not only protects dental hard tissue, but also inhibits bacterial growth and metabolism.
Ying Liao, Bernd W. Brandt, Jiyao Li, Wim Crielaard, Cor Van Loveren, Dong Mei Deng   +5 more
doaj   +1 more source

Urinary fluoride output in children following the use of a dual-fluoride varnish formulation

Journal of Applied Oral Science, 2009
OBJECTIVE: This study evaluated the bioavailability of fluoride after topical application of a dual-fluoride varnish commercially available in Brazil, when compared to DuraphatTM. MATERIAL AND METHODS: The urinary fluoride output was evaluated in seven 5-
Kelly Polido Kaneshiro Olympio, Vanessa Eid da Silva Cardoso, Maria Fernanda Borro Bijella, Juliano Pelim Pessan, Alberto Carlos Botazzo Delbem, Marília Afonso Rabelo Buzalaf   +5 more
doaj   +1 more source