Results 41 to 50 of about 415,013 (252)

Chronic sodium fluoride intake promotes changes in insulin signaling and inflammatory pathways in the skeletal muscle of rats

, 2021
This study aimed to investigate the final step of insulin signaling and the relationship between the inflammatory pathway and insulin signal attenuation in the gastrocnemius muscle (GM) of rats chronically treated with NaF. Thirty-two seven-week-old male
Pereira, Renato Felipe [UNESP], Garbin, Clea Adas Saliba [UNESP], Matsushita, Doris Hissako [UNESP], Mattera, Maria Sara de Lima Coutinho[UNESP], Santos, Rodrigo Martins dos [UNESP], Oliveira, Renan Akira Fujii de [UNESP], Penha de Oliveira, Sandra Helena [UNESP], Yamamoto Chiba, Fernando[UNESP], Tsosura, Thais Veronica Saori [UNESP], Belardi, Bianca Elvira [UNESP]   +9 more
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Remineralization potential of varnish containing casein phosphopeptides-amorphous calcium phosphate with fluoride and varnish containing only fluoride: A comparative study

Saudi Journal of Oral Sciences, 2018
Background: Fluoride varnishes have been the standard of practice for the professional application of fluoride. The primary reason for wide acceptance of fluoride varnish is that the procedure is easy, safe, convenient, and well-accepted by patients. Aim:
K L Girish Babu, Priya Subramaniam, Sangeeta Teleti   +2 more
doaj   +1 more source

BOOSTING FLUORIDE-TOOTHPASTES WITH NON-FLUORIDE AGENTS FOR CARIES CONTROL

, 2023
The widespread use of toothpastes and the limited effect of fluoride (F) on caries control have stimulated the search for agents to enhance the anticaries effect of F-containing toothpastes.
Delbem, Alberto Carlos Botazzo [UNESP], Hosida, Thayse Yumi [UNESP], Monteiro, Douglas Roberto [UNESP], Pessan, Juliano Pelim [UNESP], Sampaio, Caio [UNESP]   +4 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A conceptual model on caregivers’ hesitancy of topical fluoride for their children

PLoS ONE, 2023
Background Topical fluoride hesitancy is a well-documented and growing public health problem. Despite extensive evidence that topical fluoride is safe and prevents tooth decay, an increasing number of caregivers are hesitant about their children ...
Donald L. Chi, Darragh Kerr, Daisy Patiño Nguyen, Mary Ellen Shands, Stephanie Cruz, Todd Edwards, Adam Carle, Richard Carpiano, Frances Lewis   +8 more
doaj  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Assessment of fluoride bio-accessibility in early childhood diets

Frontiers in Oral Health
IntroductionCurrently available dietary recommendations for fluoride provided as “adequate intake” (AI) and “tolerable upper intake level” (UL) assume 100% fluoride availability for utilization by the body, which is often not the case.
Jelena Kronic, Ralph M. Duckworth, Claudio Angione, Steven M. Levy, Fatemeh Vida Zohoori   +4 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source