Results 41 to 50 of about 1,523,613 (283)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Evaluation and Comparison of Fracture Strength and Fluoride Releasing Properties of New Alkasite Materials with Conventional Restorative Material, Bulk Fill Composite and Glass Ionomer Cement: An In-Vitro Study

Journal of Pharmacy and Bioallied Sciences
Aim: This study aimed to evaluate and compare fluoride ion release by Cention-N (self-cure and light-cure) and conventional glass-ionomer cement (GIC) at different pH levels and time intervals.
Savan K. Kashiyani, Shreya A. Khanna, Leena Jobanputra, Niharika Patel, Hirenkumar P. Patel, Apoorva D. Patel   +5 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride [PDF]

, 2010
With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day)
Garbin, Clea Adas Saliba, Moimaz, Suzely Adas Saliba, Sumida, Doris Hissako, Chiba, Fernando Yamamoto, Shirakashi, Daisy Jaqueline, de Souza Gomes, Wendrew Douglas, Silva, Cristina Antoniali, Colombo, Natalia Helena   +7 more
core   +3 more sources

Comparative Evaluation of the Fluoride Recharge Ability of Two Glass Ionomers Obtained from Fluoridated Dentifrice and CPP-ACFP Paste: An In-vitro Study [PDF]

Journal of Dental Materials and Techniques, 2019
Introduction: Glass ionomer cement (GIC) is a restorative material used in pediatric dentistry, which attaches to dental hard tissues and has cariostatic properties due to the ability for fluoride release.
Karim Jafari, Saleh Hoseini, Somayeh Hekmatfar   +2 more
doaj   +1 more source

Water Fluoridation: A Critical Review of the Physiological Effects of Ingested Fluoride as a Public Health Intervention [PDF]

, 2014
Fluorine is the world’s 13th most abundant element and constitutes 0.08% of the Earth crust. It has the highest electronegativity of all elements. Fluoride is widely distributed in the environment, occurring in the air, soils, rocks, and water.
Peckham, Stephen, Stephen Peckham, Niyi Awofeso, Awofeso, Niyi   +3 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Fluoride release from conventional, resin-modified and hybrid glass ionomer cements [PDF]

Stomatološki glasnik Srbije, 2018
Introduction the aim of the study was to quantify and compare fluoride release from four different glass ionomer cement products (GICs). Materials and Methods Standardized disk-shaped samples (5x2mm; n=5/group) of GIC restorative materials: conventional (
Ležaja-Zebić Maja, Jakovljević Nikola, Miletić Vesna   +2 more
doaj  

FLUORIDE CONCENTRATIONS IN TABLE SALTS SOLD IN SUPERMARKETS OF BOGOTA, COLOMBIA

, 2021
Purpose: To determine the fluoride (F) concentrations in table salts sold in Bogota, Colombia, as well as to verify whether the values were consistent with the information provided by the manufacturers and with the standards of the national program of ...
Emi Nagata, Mariana [UNESP], Harold Estrada-Montoya, John, Carolina Baez-Quintero, Liliana [UNESP], Pelim Pessan, Juliano [UNESP], Botazzo Delbem, Alberto Carlos [UNESP]   +4 more
core