Results 51 to 60 of about 138,197 (337)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

General dentists' knowledge, attitude, and practice guidelines toward pediatric dentistry

CHRISMED Journal of Health and Research, 2020
Introduction: Pediatric dentists play an important role in treating primary teeth and providing oral health care needs for children. The prevention for diseases of the oral cavity, namely early childhood caries (ECC), abnormal oral habits, etc., at ...
Thabitha S Rani, E Rajendra Reddy, Kiranmayi Merum, M P Srujana, S Srikanth Raju, Manitha Pershad Seth   +5 more
doaj   +1 more source

Synthesis of a new class of highly fluorinated aliphatic diisocyanates [PDF]

, 1971
Synthesis is basis for preparation of polyurethanes that are compatible with liquid oxygen.
Warner, D. A.
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Study of fluoroammonium processing of reduction smelting dusts from ilmenite concentrate

Metalurgija, 2023
The article presents the results of studies on the processing of fine waste dusts of electric smelting of ilmenite concentrates. The main silicon impurity was preliminarily removed from the dusts.
Z. B. Karshyga, A. A. Ultarakova, N. G. Lokhova, A. M. Yessengaziyev, E. I. Kuldeyev, K. K. Kassymzhanov   +5 more
doaj  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

High temperature rare earth solid lubricants [PDF]

, 1970
Rare earth trifluorides have potential use as lubricating fillers for mechanical carbons and as coatings on metallic substrates.
Sliney, H. E.
core   +1 more source

Direct evidence of intervalence charge-transfer states of Eu-doped luminescent materials [PDF]

, 2019
Direct evidence is given for the existence of intervalence charge transfer (IVCT) states of Eu2+/Eu3+ pairs in Eu-doped CaF2 , SrF2, and BaF2 . They are detected in diffuse reflectance spectra.
Barandiarán, Zoila, Joos, Jonas, Seijo, Luis   +2 more
core   +2 more sources

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

Electron Lone-Pairs Stereochemistry and Drastic van der Waals and Pressure Effects in AsF₃ from First Principles

Condensed Matter, 2021
AsF3E as a representative of a molecular crystal has been chosen to find the precise localization of the lone pair (LP) E centroid 4s2 of As3+ and to enlighten the behavior of lone pair triplets of fluorine atoms. Starting from stereochemistry rationale,
Jean Galy, Samir F. Matar
doaj   +1 more source