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The Radiopharmaceutical Chemistry of Fluorine-18: Nucleophilic Fluorinations [PDF]

Radiopharmaceutical Chemistry, 2019
The positron-emitting radionuclide fluorine-18 plays a prominent role in radiopharmaceuticals for positron emission tomography (PET) due to its favourable nuclear decay properties. Depending on the production method, 18F can be obtained in two different chemical forms: electrophilic [18F]fluorine gas and nucleophilic [18F]fluoride.
Johannes Ermert, Bernd Neumaier
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Fluorine-18 Radiolabelling and Photophysical Characteristics of Multimodal PET-Fluorescence Molecular Probes.

Chemistry, 2020
Positron emission tomography (PET)-fluorescence imaging is an emerging field of multimodality imaging seeking to attain synergy between the two techniques.
M. Klenner, G. Pascali, Massimiliano Massi, Benjamin H. Fraser   +3 more
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The half-life of fluorine-18 [PDF]

Journal of Inorganic and Nuclear Chemistry, 1964
Radiochemically pure 18F has been prepared by three different methods and its decay has been followed with β proportional counters and γ-ray counters in an effort to measure the half-life accurately. Analysis by a computer program that used the method of least squares gave a weighted mean half-life of 18F and a weighted standard deviation of the mean ...
J.D. Mahony, Samuel S. Markowitz
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Production of reactive fluorine-18

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1986
Production conditions are reviewed from the perspective of maximizing activity--both total and specific--of 18F as electrophilic or nucleophilic precursors, with minimal levels of interfering species. Careful target design can avoid many pitfalls, and telemetry of a few key variables can guide the way to reproducible yields, consistent with prediction.
Robert J. Nickles, S. John Gatley, John R. Votaw, Margaret L. Kornguth   +3 more
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PET imaging of musculoskeletal tumours with fluorine-18 α-methyltyrosine: comparison with fluorine-18 fluorodeoxyglucose PET [PDF]

European Journal of Nuclear Medicine, 2000
Fluorine-18 labelled alpha-methyltyrosine (FMT) was developed for positron emission tomography (PET) imaging, and its potential for clinical application in patients with brain tumours has been demonstrated. This is the first trial to compare FMT with 18F-fluoro-2-deoxy-D-glucose (FDG) for the evaluation of musculoskeletal tumours. Seventy-five patients
Kenji Takagishi, Noboru Oriuchi, Tomio Inoue, Adel Refaat Ahmed, Keigo Endo, Takashi Yanagawa, Mari Tokunaga, Hideomi Watanabe, Katsumi Tomiyoshi, Jun Aoki, Tetsuya Shinozaki   +10 more
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The Preparation of Fluorine-18 Labelled Radiopharmaceuticals

The International Journal of Applied Radiation and Isotopes, 1977
Abstract Progress in the preparation of fluorine-18 labelled radiopharmaceuticals is reviewed. The pharmacology and design of 18F-labelled organic compounds of biomedical interest, production of the radionuclide and methods of labelling which have been used to date are discussed. Emphasis has been placed on the practical chemical problems encountered,
A K, Horsch, K, Hudson, R W, Goulding, A J, Day   +3 more
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Therapy Monitoring with Fluorine-18 FDG-PET and Fluorine-18 FDG-PET/CT

PET Clinics, 2008
PET with the glucose analog [18F]-FDG is increasingly used to monitor tumor response in patients undergoing chemotherapy and chemoradiotherapy. The clinical value of FDG PET for differentiation of residual tumor and therapy-induced fibrosis has been documented for gastrointestinal cancer.
Ken Herrmann, Hinrich Wieder
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Fluorine 18-FDG PET/CT and Diffusion-weighted MRI for Malignant versus Benign Pulmonary Lesions: A Meta-Analysis.

Radiology, 2019
Purpose To perform a meta-analysis of the literature to compare the diagnostic performance of fluorine 18 fluorodeoxyglucose PET/CT and diffusion-weighted (DW) MRI in the differentiation of malignant and benign pulmonary nodules and masses. Materials and
Adriano Basso Dias, M. Zanon, S. Altmayer, Gabriel Sartori Pacini, Natália Henz Concatto, G. Watte, A. Garcez, T. Mohammed, Nupur Verma, T. Medeiros, E. Marchiori, K. Irion, B. Hochhegger   +12 more
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Metabolism of Fluorine 18 in Domestic Animals

American Journal of Physiology-Legacy Content, 1955
Amounts of F/sup 18/ sufficient to permit studies up to 10 hours duration in domestic animals with non-toxic levels of total fluorine have become available from cyclotron production. The initial rate of disappearance of intravenously injected F/sup 18/ from the blood was found to be 41 and 32% of the dose/min.
Robert A. Monroe, W. E. Lotz, Jesse D. Perkinson, C. L. Comar, Ira B. Whitney   +4 more
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Recommendations for fluorine-18 production

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1991
Abstract Data for the production of fluorine-18 (t 1/2 = 109.6 min; β + = 100%) are reviewed. The experience of some well-established European centres for positron emission tomography (PET), in the routine production of fluorine-18 for the purpose of labelling radiopharmaceuticals, is described.
Guillaume, Marcel, Luxen, André, Nebeling, Bruno, Argentini, Mario, Clark, John W., Pike, Victor William   +5 more
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