Results 81 to 90 of about 53,359 (237)

Applications of radiation in photodiagnosis and photodynamic therapy [PDF]

, 2020
The application of radiation to porphyrin-based photosensitisers for the purposes of photodiagnosis and photodynamic therapy have been described in an effort to explore combined therapies, which seek to extend the use of photodynamic therapy beyond its ...
Entract, Guy
core  

Radiosynthesis and Radiotracer Properties of a 7-(2-[18F]Fluoroethoxy)-6-methoxypyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET

Pharmaceuticals, 2012
Phosphodiesterase 10A (PDE10A) is a key enzyme of intracellular signal transduction which is involved in the regulation of neurotransmission. The molecular imaging of PDE10A by PET is expected to allow a better understanding of physiological and ...
Detlef Briel, Peter Brust, Achim Hiller, Gregor Schwan, Aurélie Maisonial, Matthias Scheunemann, Steffen Fischer, Winnie Deuther-Conrad, Uta Funke   +8 more
doaj   +1 more source

18F-Labeled Peptides: The Future Is Bright

Molecules, 2014
Radiolabeled peptides have been the subject of intense research efforts for targeted diagnostic imaging and radiotherapy over the last 20 years. Peptides offer several advantages for receptor imaging and targeted radiotherapy. The low molecular weight of
Susan Richter, Frank Wuest
doaj   +1 more source

The Radiolabeling of a Gly-Sar Dipeptide Derivative with Flourine-18 and Its Use as a Potential Peptide Transporter PET Imaging Agent

Molecules, 2020
We have developed a novel fluorine-18 radiotracer, dipeptide 1, radiolabeled in two steps from mesylate 3. The initial radiolabeling is achieved in a short reaction time (10 min) and purified through solid-phase extraction (SPE) with modest radiochemical
Andrei Molotkov, John W. Castrillon, Sreevidya Santha, Paul E. Harris, David K. Leung, Akiva Mintz, Patrick Carberry   +6 more
doaj   +1 more source

Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase [PDF]

, 2016
We thank EPSRC and the Scottish Imaging Network (SINAPSE) for grants. DO’H thanks the Royal Society for a Wolfson Research Merit Award and ST is grateful to the John and Kathleen Watson Scholarship for financial support.
Fleming, Ian N., O’Hagan, David, Thompson, Stephen   +2 more
core   +1 more source

Development of a PET probe for the imaging of COX-2 expression in cancers [PDF]

, 2015
The COX-2 isozyme is overexpressed in several kinds of cancer, including colorectal, lung, breast, and oesophageal cancer. High levels of COX-2 are usually associated with poor prognosis and advanced disease.
Pacelli, Anna
core   +1 more source

[¹⁸F]-Radiolabelled Nanoplatforms: A Critical Review of Their Intrinsic Characteristics, Radiolabelling Methods, and Purification Techniques

Molecules
A wide range of nano-objects is found in many applications of our everyday life. Recognition of their peculiar properties and ease of functionalization has prompted their engineering into multifunctional platforms that are supposed to afford efficient ...
Maëlle Deleuziere, Éric Benoist, Isabelle Quelven, Emmanuel Gras, Catherine Amiens   +4 more
doaj   +1 more source

Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT) [PDF]

, 2011
The purpose of this study was to analyze the detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT). Data for a total of 492 patients who had undergone both PET/CT
A Katagiri, B Levin, BR Weston, CD Johnson, CG Fraser, D Ravizza, D Thorwarth, DF Halpenny, Eisuke Kaji, EM Kamel, EM Rohren, F Gutman, FA Sinicrope, H Pohl, Hideyuki Suzuki, J Czernin, JP Drenth, Jun Kato, Kazuhide Yamamoto, Keisuke Hori, KS Tagore, MB Tessem, MC Kouwen van, Mitsuhiro Akita, O Israel, PL Kei, R Meza, R Minamimoto, R Tatlidil, Reiji Higashi, S Friedland, S Halligan, S Kudo, S Kudo, S Tsuda, S Yasuda, Sakiko Hiraoka, Sakuma Takahashi, Shunsuke Saito, SS Shim, TF Imperiale, Tomoko Hirakawa, Toshio Uraoka, WS Samowitz, Y Zhao, Yoshihiro Okumura   +45 more
core   +1 more source

Synthesis of [ 18 F]fluoroethoxy‐benzovesamicol, a radiotracer for cholinergic neurons [PDF]

, 1993
Full experimental details are given for the preparation of [ 18 F]fluoroethoxy‐benzovesamicol, (−)‐( 2R, 3R )‐ trans ‐2‐hydroxy‐3‐(4‐phenylpiperidino)‐5‐(2‐[ 18 F]fluoroethoxy)‐1,2,3,4‐tetralin, a new fluorine‐18 labeled cholinergic neuron mapping agent ...
Altar, Block, Block, Chi, Dale, Efange, French, Hicks, Jerabek, Jung, Keisewetter, Kiesewetter, Kilbourn, Lemaire, Marien, Marshall, Moerlein, Mulholland, Mulholland, Mulholland, Mulholland, Mulholland, Mulholland, Plenevaux, Rogers, Rogers, Rogers, Rogers, Satymurthy, Shuie, Suehiro, Widen   +31 more
core   +1 more source

Preclinical validations of [18F]FPyPEGCBT-c(RGDfK): a 18F-labelled RGD peptide prepared by ligation of 2-cyanobenzothiazole and 1,2-aminothiol to image angiogenesis

EJNMMI Radiopharmacy and Chemistry, 2016
Background αVβ3, αVβ5 and α5β1 integrins are known to be involved in carcinogenesis and are overexpressed in many types of tumours compared to healthy tissues; thereby they have been selected as promising therapeutic targets. Positron emission tomography
Didier J. Colin, James A. H. Inkster, Stéphane Germain, Yann Seimbille   +3 more
doaj   +1 more source