Results 61 to 70 of about 12,307 (185)

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source

Benzoxazinoid‐mediated microbiome feedbacks enhance Arabidopsis growth and defence

New Phytologist, EarlyView.
Summary Plants modulate their surrounding microbiome via root exudates and such conditioned soil microbiomes feed back on the performance of the next generation of plants. How plants perceive altered soil microbiomes and modulate their performance in response to such microbiome feedbacks, however, remains largely unknown.
Katja Stengele, Lea Stauber, Lisa Thoenen, Henry Janse van Rensburg, Viola D'Adda, Klaus Schlaeppi   +5 more
wiley   +1 more source

Novel Flurometric Tool to Assess Mitochondrial Redox State of Isolated Perfused Rat Lungs After Exposure to Hyperoxia

IEEE Journal of Translational Engineering in Health and Medicine, 2013
Recently, we demonstrated the utility of optical fluorometry to detect a change in the redox status of mitochondrial autofluorescent coenzymes nicotinamide adenine dinucleotide (NADH) and oxidized form of flavin adenine dinucleotide (FADH2) (FAD), as a ...
Reyhaneh Sepehr, Said H. Audi, Kevin S. Staniszewski, Steven T. Haworth, Elizabeth R. Jacobs, Mahsa Ranji   +5 more
doaj   +1 more source

Loss of qE Does Not Necessarily Lead to Photoinhibition: Sustained Non‐Photochemical Quenching in the Absence of PsbS and Zeaxanthin

Plant, Cell &Environment, EarlyView.
ABSTRACT Photosynthetic light‐harvesting complexes mediate light absorption and energy dissipation. By modulating the photosystems' absorption cross‐section, they affect both photosynthetic activity and non‐photochemical quenching (NPQ). These processes are often studied by spectrally integrated chlorophyll fluorescence, masking their associated ...
Maximiliano Cainzos, Chen Hu, Maria Dolores Pissolato, Nazeer Fataftah, Sanchali Nanda, Stefan Jansson   +5 more
wiley   +1 more source

High-Sensitivity Fluorometry to Resolve Ion Channel Conformational Dynamics

Cell Reports, 2018
Summary: Fluorescent labels offer the capability to follow conformational dynamics of membrane proteins, but signal detection in such recordings is inherently difficult to achieve in a cell membrane and lacks sufficient time resolution to follow ...
Matthias Wulf, Stephan Alexander Pless
doaj   +1 more source

Circular RNAs in Lotus japonicus Responses to Nutrient Supply and Mesorhizobium Symbiosis

Plant, Cell &Environment, EarlyView.
ABSTRACT Symbiotic interactions between legumes and rhizobia enable nitrogen fixation under low nutrient conditions. The establishment and function of symbiotic interactions require coordinated changes in gene expression in both the host and the microbe. Circular RNAs (circRNAs) are endogenous gene‐specific molecules that can regulate transcription and
Delecia Utley, Asa Budnick, Simona Radutoiu, Heike Sederoff   +3 more
wiley   +1 more source

Skin Commensal Microbiota Does Not Influence the Clinical Course of Dermatophyte Infection in Persian Cats

Veterinary Dermatology, EarlyView.
Dermatophytes can be isolated from both symptomatic and asymptomatic cats, yet the role of skin commensals in modulating disease expression remains unclear. This study investigates whether microbial skin communities influence the clinical presentation (symptomatic or asymptomatic) of dermatophyte infection in Persian cats.
Aline E. Santana, Sheila M. F. Torres, Matheus de O. Costa   +2 more
wiley   +1 more source

Moderate‐Temperature Hydrothermal Treatment Removes Detectable DNA and Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value

Water and Environment Journal, EarlyView.
This graphical abstract shows the overall study design where dewatered wastewater sludge samples were collected and subjected to a range of HT temperatures. Measurement of nucleic acid concentration and antibiotic resistance gene profiles across temperatures showed that HT at moderate temperatures offers sustainable, scalable sludge sanitation and ARG ...
R. Sean Norman, Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge   +3 more
wiley   +1 more source

Mitochondrial respiration and hydrogen peroxide production rate in right atrial tissues from obese diabetic patients

Experimental Physiology, EarlyView.
Abstract Type 2 diabetes (T2D) is a global epidemic, with heart failure being the leading cause of premature death. Mitochondrial dysfunction, characterized by impaired energy metabolism, weakened energy transport system and increased oxidative stress, has been proposed as a key contributor to the impairment of contractile function in T2D hearts ...
Toan Pham, Sarbjot Kaur, Anthony Hickey, Marie‐Louise Ward, Kenneth Tran   +4 more
wiley   +1 more source

Development of Quantifiable Assays for Detection of Hypersialylation in Oral Cancer Diagnosis

Indian Journal of Dental Sciences
Aim: The aim of this study is to Quantify sialic acid for oral cancer diagnosis using different method using densitometric analysis. Background: Early detection of OSCC is critical for improving survival rates and reducing morbidity, which has prompted ...
Shrutam Somkuwar, Shravasti Jangle, Vedanti Morey, Devyani Salotkar, Shreya Reddy, Aparna Nair, Deovrat Begde   +6 more
doaj   +1 more source