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The Newer Fluoroquinolones [PDF]
Medical Clinics of North America, 2009 Clinicians have enthusiastically used fluoroquinolones owing to their good safety profile and wide range of indications. This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and ...
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Ophthalmology, 2009
To report a possible association between fluoroquinolones and diplopia.Database study.A total of 171 subjects were studied.Spontaneous reports from the National Registry of Drug-Induced Ocular Side Effects, World Health Organization, and Food and Drug Administration were collected on fluoroquinolones and diplopia.Data garnered from the spontaneous ...
Frederick W. Fraunfelder +1 more
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To report a possible association between fluoroquinolones and diplopia.Database study.A total of 171 subjects were studied.Spontaneous reports from the National Registry of Drug-Induced Ocular Side Effects, World Health Organization, and Food and Drug Administration were collected on fluoroquinolones and diplopia.Data garnered from the spontaneous ...
Frederick W. Fraunfelder +1 more
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Fluoroquinolone Use and Fluoroquinolone Resistance: Is There an Association?
Clinical Infectious Diseases, 1994In an assessment of potential risk factors for nosocomial infections caused by fluoroquinolone-resistant gram-negative organisms, 68 patients who developed a nosocomial infection caused by a fluoroquinolone-resistant gram-negative bacillus were compared with 191 patients who developed a nosocomial infection caused by a fluoroquinolone-susceptible gram ...
Hervé Richet +6 more
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Towards anticancer fluoroquinolones: A review article
Archiv der Pharmazie, 2019Different studies about the anticancer potential of several medically used antibacterial fluoroquinolones have been established. Fluoroquinolone derivatives, like some anti‐cancer drugs, such as doxorubicin, can achieve antitumor activity via poisoning ...
M. Abdel-Aal +3 more
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Fluoroquinolones and tuberculosis
Expert Opinion on Investigational Drugs, 2002Tuberculosis (TB) remains one of the main causes of morbidity worldwide, and the emergence of multi-drug resistant (MDR) Mycobacterium tuberculosis strains in some parts of the world has become a major concern. The decrease in activity of the major anti-TB drugs, such as isoniazid and rifampicin, is an important threat and alternative therapies are ...
André Bryskier, John Lowther
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Mayo Clinic Proceedings, 1999
The quinolones are broad-spectrum antibacterial agents that have a novel mechanism of action. As synthetic compounds, these agents have been developed extensively to optimize antimicrobial activity, pharmacokinetic properties, and drug safety. Although earlier quinolones were effective only in the genitourinary and gastrointestinal tracts and only had ...
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The quinolones are broad-spectrum antibacterial agents that have a novel mechanism of action. As synthetic compounds, these agents have been developed extensively to optimize antimicrobial activity, pharmacokinetic properties, and drug safety. Although earlier quinolones were effective only in the genitourinary and gastrointestinal tracts and only had ...
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Fluoroquinolones in Paediatrics
Drugs, 1999Fluoroquinolones have a broad spectrum of activity against gram-positive, gram-negative, and mycobacterial organisms as well as anaerobes, Mycoplasma, Chlamydia, Ureaplasma, and Legionella spp. They have excellent oral bioavailability, with good tissue penetration, and long elimination half-lives. The experience with fluoroquinolones in paediatrics has
George H. McCracken, Hasan S. Jafri
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Infectious Disease Clinics of North America, 2004
This article discusses the newer fluoroquinolones in detail with respect to their pharmacokinetics, pharmacodynamics, safety, and spectrum of in vitro activity. The newer agents are compared and contrasted with the older ones, particularly ciprofloxacin.
Steven P. Gelone, Judith A. O'Donnell
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This article discusses the newer fluoroquinolones in detail with respect to their pharmacokinetics, pharmacodynamics, safety, and spectrum of in vitro activity. The newer agents are compared and contrasted with the older ones, particularly ciprofloxacin.
Steven P. Gelone, Judith A. O'Donnell
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Infectious Disease Clinics of North America, 1995
Since the introduction of the floroquinolones for clinical use in the late 1980s, they have been used successfully for a large number of clinical situations. As experience accumulates, the indications and optimal use of these agents gradually become more clear.
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Since the introduction of the floroquinolones for clinical use in the late 1980s, they have been used successfully for a large number of clinical situations. As experience accumulates, the indications and optimal use of these agents gradually become more clear.
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Dysglycaemias and Fluoroquinolones
Drug Safety, 2008The fluoroquinolones are an extremely popular class of antibacterials, owing to their broad spectrum of activity and the convenience of their intravenous and oral dosage formulations. Overall, the currently available fluoroquinolones have a good safety profile; however, certain fluoroquinolones within the class have been associated with severe and life-
Roshan J. Lewis, John F. Mohr
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