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Enantioselective Detection, Bioactivity, and Metabolism of the Novel Chiral Insecticide Fluralaner

Journal of Agricultural and Food Chemistry, 2020
Fluralaner, a veterinary drug, is a potential chiral isoxazoline insecticide possessing high insecticidal and acaricidal activity. However, there is little information regarding the enantioselective effect of fluralaner. In this work, a promising chiral detection method was established with liquid chromatography-mass spectrometry in agricultural ...
Zhaoxian Zhang   +6 more
openaire   +2 more sources

Theoretical and Experimental Study of Molecular Interactions of Fluralaner with Lipid Membranes

Journal of Agricultural and Food Chemistry, 2023
Fluralaner is a relatively new insecticide belonging to the isoxazoline group, whose action mechanism involves the blocking of GABAA-receptors in the insect nervous system. Because of its high hydrophobicity, fluralaner could bioaccumulate and reach toxic local concentrations.
María Salomé Gastaldi   +4 more
openaire   +3 more sources

Treatment of crusted sarcoptic mange with fluralaner in a dog

Veterinary Record Case Reports, 2021
Abstract A 4‐year‐old neutered male Lakeland terrier was presented for evaluation of allergies and onset of new crusting skin lesions. The face, dorsum, limbs and paws were diffusely covered in crusts and adherent scaling. The dog was mildly to moderately pruritic.
Laura L. Quilling   +3 more
openaire   +1 more source

Insecticidal spectrum of fluralaner to agricultural and sanitary pests

Journal of Asia-Pacific Entomology, 2017
Abstract Fluralaner, as an isoxazoline insecticide, has been developed as antiparasitic (namely Bravecto®) with selective toxicity for insect versus mammals. Even though the toxic effect of fluralaner to several insects have been already examined, but also more agricultural and sanitary insects should be tested before it could be used widely.
Cheng-Wang Sheng   +9 more
openaire   +1 more source

Toxicity and sublethal effects of fluralaner on Spodoptera litura Fabricius (Lepidoptera: Noctuidae)

Pesticide Biochemistry and Physiology, 2018
The increasing occurrence of resistance to chemical insecticides in insect pest populations is a serious threat to the integrity of current pest management strategies, and exploring new alternative chemistries is one important way to overcome this obstacle. Fluralaner, as a novel isoxazoline insecticide, has broad spectrum activity against a variety of
Di Liu   +7 more
openaire   +2 more sources

Putative pemphigus‐like reaction to oral fluralaner in a dog

Veterinary Dermatology
AbstractA 9‐month‐old mixed‐breed dog developed generalised pustular dermatitis, accompanied by lethargy and hyperthermia, 7 days after oral fluralaner administration. Dermatopathological and microbiological evaluations were consistent with a pustular acantholytic dermatitis.
Annabel Dalmau, Laura Ordeix
openaire   +2 more sources

Acute toxicity, bioconcentration, elimination and antioxidant effects of fluralaner in zebrafish, Danio rerio

Environmental Pollution, 2018
Fluralaner is a novel isoxazoline insecticide which shows high insecticidal activity against parasitic, sanitary and agricultural pests, but there is little information about the effect of fluralaner on non-target organisms. This study reports the acute toxicity, bioconcentration, elimination and antioxidant response of fluralaner in zebrafish.
Zhong-Qiang Jia   +8 more
openaire   +2 more sources

Mosquitocidal activity and mode of action of the isoxazoline fluralaner

2016 International Congress of Entomology, 2016
In the series University of Florida Digital Collections. ; Includes vita. ; (Bibliography) Includes bibliographical references. ; (Source of Description) Description based on online resource; title from PDF title page. ; (Source of Description) This bibliographic record is available under the Creative Commons CC0 public domain dedication.
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Neurotoxicity and mode of action of fluralaner on honeybee Apis mellifera L.

Pest Management Science, 2019
AbstractBACKGROUNDFluralaner, a novel pesticide that targets the γ‐aminobutyric acid (GABA) receptor (GABAR) subunit of resistant to dieldrin (RDL), exhibits strong potential to be an insecticide to control agricultural insect pests. However, the risk and action of fluralaner to economic insects, e.g., honeybee Apis mellifera Linnaeus, remains unclear ...
Cheng‐Wang Sheng   +7 more
openaire   +2 more sources

Bioequivalence of fluralaner-based veterinary medicinal products: VEPRIPAK® and BRAVECTO®

Russian veterinary journal
General information: fluralaner is a systemic ectoparasiticide that provides long-term control of fleas and ticks in dogs after a single oral administration. Based on this compound, VETSTEM LLC has developed a new veterinary medicinal product, VEPRIPAK®.
Liliya Fedulova   +2 more
openaire   +1 more source

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