Results 21 to 30 of about 6,780 (162)

Efficacy and safety of parecoxib and flurbiprofen axetil for perioperative analgesia in children: a network meta-analysis

Frontiers in Medicine, 2023
ObjectiveThe aim of this study was to systematically review the efficacy and safety of parecoxib and flurbiprofen axetil for perioperative analgesia in children through Bayesian network meta-analysis.MethodsWe systematically searched PubMed, Embase ...
Xi Chen, Xi Chen, Pan Chen, Xiao Chen, Min Huang, Kejing Tang, Qiuyi He   +6 more
doaj   +1 more source

R‐flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice

EMBO Molecular Medicine, 2014
R‐flurbiprofen is the non‐cyclooxygenase inhibiting R‐enantiomer of the non‐steroidal anti‐inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease.
Katja Schmitz, Natasja de Bruin, Philipp Bishay, Julia Männich, Annett Häussler, Christine Altmann, Nerea Ferreirós, Jörn Lötsch, Alfred Ultsch, Michael J Parnham, Gerd Geisslinger, Irmgard Tegeder   +11 more
doaj   +1 more source

Flurbiprofen Axetil Enhances Analgesic Effects of Sufentanil and Attenuates Postoperative Emergence Agitation and Systemic Proinflammation in Patients Undergoing Tangential Excision Surgery

Mediators of Inflammation, 2015
Objective. Our present study tested whether flurbiprofen axetil could reduce perioperative sufentanil consumption and provide postoperative analgesia with decrease in emergency agitation and systemic proinflammatory cytokines release. Methods.
Wujun Geng, Wandong Hong, Junlu Wang, Qinxue Dai, Yunchang Mo, Kejian Shi, Jiehao Sun, Jinling Qin, Mei Li, Hongli Tang   +9 more
doaj   +1 more source

Intravenous flurbiprofen for post-thymectomy pain relief in patients with myasthenia gravis

Journal of Cardiothoracic Surgery, 2012
Background Post-thymectomy pain in myasthenia gravis (MG) patients can inhibit breathing and coughing. Inappropriate usage of analgesics may exacerbate respiratory inhibition and even cause myasthenic crisis.
Su Chunhua, Su Yihua, Chou Chiu-Wen, Liu Weibing, Zou Jianyong, Luo Honghe, Chen Zhenguang   +6 more
doaj   +1 more source

Randomized, controlled clinical study to evaluate efficacy of novel indigenously designed controlled release flurbiprofen gel system for management of periodontal diseases

Contemporary Clinical Dentistry, 2013
Background: This randomized, controlled clinical study was planned to evaluate the use of anti-inflammatory drug flurbiprofen in the form of locally delivered controlled release gel in the treatment of periodontal disease.
Neeraj C Deshpande, K M Bhat, G S Bhat, Anshula N Deshpande   +3 more
doaj   +1 more source

Effect of non-steroidal anti-inflammatory drugs on growth and functional activity of osteoblasts in vitro

陆军军医大学学报
Objective To investigate the effects of new and traditional non-steroidal anti-inflammatory drugs (NSAIDs) on the proliferation, morphology, adhesion, activity and expression of osteoblast related genes of MG-63 osteoblasts by establishing a osteogenic ...
XIE Meng, MO Anchun
doaj   +1 more source

Determination of the Permeation and Penetration of Flurbiprofen into Cadaveric Human Pharynx Tissue

Clinical Pharmacology: Advances and Applications, 2020
Rob Turner,1 Sean Robert Wevrett,1 Suzanne Edmunds,1 Marc B Brown,1,2 Robert Atkinson,3 Oluwajoba Adegoke,3 Anuradha Kulasekaran,4 Tim Shea5 1MedPharm Ltd, Surrey Research Park, Guildford, UK; 2The Research Centre in Topical Drug Delivery and Toxicology (
Turner R, Wevrett SR, Edmunds S, Brown MB, Atkinson R, Adegoke O, Kulasekaran A, Shea T   +7 more
doaj  

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source