Results 51 to 60 of about 6,780 (162)

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

open access: yesAdvanced Functional Materials, Volume 36, Issue 16, 23 February 2026.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee   +4 more
wiley   +1 more source

Inhibition of endocannabinoid metabolism by the metabolites of ibuprofen and flurbiprofen.

open access: yesPLoS ONE, 2014
BackgroundIn addition to their effects upon prostaglandin synthesis, the non-steroidal anti-inflammatory drugs ibuprofen and flurbiprofen inhibit the metabolism of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA) by cyclooxygenase ...
Jessica Karlsson, Christopher J Fowler
doaj   +1 more source

Gut Bacterium Lysinibacillus Sphaericus Exacerbates Aspirin‐induced Intestinal Injury by Production of Carboxylesterase EstB

open access: yesAdvanced Science, Volume 13, Issue 12, 27 February 2026.
Schematic overview illustrating the detrimental role of gut microbiota in aspirin‐induced intestinal injury. L. sphaericus and its secreted carboxylesterase EstB are identified as key drivers that catalyze aspirin hydrolysis into salicylic acid, thereby exacerbating intestinal injury. Inhibition of EstB by the dietary compound flavanomarein effectively
Zeyu Zhao   +13 more
wiley   +1 more source

Economic Burden of Sickle Cell Disease: A Retrospective Study of Pediatric and Adult Individuals With Medicaid Coverage From 2016 to 2020

open access: yesAmerican Journal of Hematology, Volume 101, Issue 2, Page 269-280, February 2026.
ABSTRACT There is limited information regarding the contemporary real‐world clinical and financial burden of Medicaid enrollees with sickle cell disease (SCD) in the United States. Using the IBM MarketScan Medicaid database (7/2016–12/2020), individuals with ≥ 3 SCD diagnoses were matched 1:1 on age, gender, and race to individuals without SCD ...
Giovanna Tedesco Barcelos   +4 more
wiley   +1 more source

Population pharmacokinetic modeling of flurbiprofen, the active metabolite of flurbiprofen axetil, in Chinese patients with postoperative pain

open access: yesJournal of Pain Research, 2018
Jingru Zhang,1,2,* Hong Zhang,1,* Libo Zhao,3 Jian Gu,4 Yi Feng,1 Haiyan An1 1Department of Anesthesiology, Peking University People’s Hospital, Beijing 100044, China; 2Department of Pharmacy Administration and Clinical Pharmacy, School of ...
Zhang J   +5 more
doaj  

Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress

open access: yesEMBO Molecular Medicine, 2014
Endoplasmic reticulum (ER) stress, caused by the accumulation of unfolded proteins, is involved in the development of obesity. We demonstrated that flurbiprofen, a nonsteroidal anti‐inflammatory drug (NSAID), exhibited chaperone activity, which reduced ...
Toru Hosoi   +9 more
doaj   +1 more source

Microscale Affinity Chromatography for Biointeraction Analysis: Strategies, Principles and Applications

open access: yesJournal of Separation Science, Volume 49, Issue 2, February 2026.
ABSTRACT The analysis of interactions between biological agents or with surrounding chemicals is important in many areas of modern biochemical, biomedical, and environmental research. Microscale platforms based on affinity chromatography have been shown to be a powerful set of tools for these studies.
David S. Hage   +8 more
wiley   +1 more source

Effect of flurbiprofen sodium on pupillary dilatation during scleral buckling surgery

open access: yesIndian Journal of Ophthalmology, 1994
Maintenance of pupillary dilatation is necessary for success of scleral buckling procedures. The efficacy of 0.03% flurbiprofen in preventing intraoperative miosis was evaluated by a prospective randomized, double-masked controlled trial of 60 ...
Roysarkar T   +4 more
doaj  

Flurbiprofen ameliorates glucose deprivation-induced leptin resistance

open access: yesFrontiers in Pharmacology, 2016
Leptin resistance is one of the mechanisms involved in the pathophysiology of obesity. The present study showed that glucose deprivation inhibited leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) and signal ...
Toru Hosoi   +3 more
doaj   +1 more source

A simple high-performance liquid chromatographic practical approach for determination of flurbiprofen

open access: yesJournal of Advanced Pharmaceutical Technology & Research, 2011
A simple, rapid, sensitive, and specific high-performance liquid chromatography (HPLC) assay for flurbiprofen has been developed and validated practically.
Muhammad Akhlaq   +6 more
doaj   +1 more source

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