Results 101 to 110 of about 1,149 (154)

Developmental Cardiotoxicity and Hepatotoxicity of Flurbiprofen Axetil to Zebrafish Embryo

ASSAY and Drug Development Technologies, 2022
Flurbiprofen axetil (FA) is a nonsteroidal targeted analgesic and widely used for postoperative analgesia and cancer analgesia. Extensive works have been done in the evaluation of FA's clinical analgesic effect on adults. Along with the increase of FA usage, the potential toxicity and molecular mechanism in embryo development need to be better ...
Yuping Wang, Min Zhou, Jing Wang, Chuantao Lin, Xiang Gao, Li Zhang, Wenshui Yao, Longxin Zhang   +7 more
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Comparison of in vivo pharmacokinetic behaviors of R‐ and S‐flurbiprofen after intravenous injection of flurbiprofen axetil

Chirality, 2023
AbstractFlurbiprofen axetil (FA) is a prodrug of flurbiprofen (FP), and it is hydrolyzed to the active FP by carboxylesterase in plasma after intravenous injection. The pharmacological action of FP is closely related to its chirality, and S‐FP shows better analgesic effects than R‐FP.
Yan He, Mengdi Qin, Mo Li, Defu Zhi, Baocheng Tian, Feng Qin   +5 more
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Flurbiprofen Axetil, Nasal Polyps, and Status Asthmaticus: An Unusual Case Report

Journal of Asthma, 2011
Herein, we report a case of life-threatening status asthmaticus in a young male presented with nasal polyps but without any history of anaphylaxis or asthma.The patient had normal results from preoperative respiratory systemic examinations. The postoperative asthma, which started after an infusion of nonsteroidal anti-inflammatory drugs (NSAIDs), was ...
Wenchong, Sun, Ling, Pei
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RETRACTED: Pretreatment with flurbiprofen axetil, flurbiprofen axetil preceded by venous occlusion, and a mixture of flurbiprofen axetil and propofol in reducing pain on injection of propofol in adult Japanese surgical patients: A prospective, randomized, double-blind, placebo-controlled study

Clinical Therapeutics, 2009
Pain on injection of propofol is a common clinical problem. Flurbiprofen axetil, an injectable prodrug of flurbiprofen, with or without venous occlusion has been reported to reduce this pain. A search of the existing literature did not identify comparative studies of 3 different techniques, including pretreatment with flurbiprofen axetil, flurbiprofen ...
Yoshitaka, Fujii, Michiyo, Itakura
openaire   +2 more sources

Absorption kinetics of flurbiprofen axetil microspheres in cerebrospinal fluid: A pilot study

Int. Journal of Clinical Pharmacology and Therapeutics, 2017
The purpose of this study is to investigate the absorption dynamics of flurbiprofen axetil in cerebrospinal fluid.We analyzed the concentrations of flurbiprofen in peripheral venous blood and cerebrospinal fluid (CSF) to explore the absorption dynamics of flurbiprofen axetil loaded in lipid microspheres in CSF.
Hong, Zhang, Jian, Gu, Yi, Feng, Haiyan, An   +3 more
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Flurbiprofen axetil protects against cerebral ischemia/reperfusion injury via regulating miR‐30c‐5p and SOX9

Chemical Biology & Drug Design, 2021
AbstractThe modulatory mechanism of flurbiprofen axetil (FPA) by which it relieves cerebral ischemia/reperfusion (I/R) injury (CIRI) is still obscure. In the present work, adult male Sprague‐Dawley (SD) rats were pre‐treated with FPA before the construction of a rat model of CIRI.
Bangkun, Yang, Ying, Nie, Lesheng, Wang, Wenping, Xiong   +3 more
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Application effect of dexmedetomidine combined with flurbiprofen axetil and flurbiprofen axetil monotherapy in radical operation of lung cancer and evaluation of the immune function.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2022
To explore the effect of dexmedetomidine combined with flurbiprofen axetil on postoperative analgesia and immune function in patients with lung cancer after radical operation.60 lung cancer patients undergoing open chest radical surgery were selected and randomly divided into D & F Group (dexmedetomidine combined with flurbiprofen axetil) and F Group ...
Shilan, Zong, Jianguo, Du, Yuanyuan, Chen, Hong, Tao   +3 more
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Intravenous Flurbiprofen Axetil To Relieve Cancer-Related Multiple Breakthrough Pain: A Clinical Study

Journal of Palliative Medicine, 2013
To compare the treatment effect reducing cancer-related multiple breakthrough pain (BTP) between immediate release morphine sulfate (IRMS) and flurbiprofen axetil.Eligible patients with refractory BTP were divided into two groups; the control group received IRMS for rescue care; the flurbiprofen group received intravenous flurbiprofen axetil.
Jianlei, Hao, Kun, Wang, Yuejuan, Shao, Xianjiang, Cheng, Zhe, Yan   +4 more
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Preoperative administration of intravenous flurbiprofen axetil reduces postoperative pain for spinal fusion surgery

Journal of Anesthesia, 2006
The aim of the study was to investigate postoperative analgesia and the opioid-sparing effect of the preoperative administration of intravenous flurbiprofen axetil in patients undergoing spinal fusion surgery.Thirty-six patients were randomly allocated into one of three groups. Group A received preoperative flurbiprofen axetil, 1 mg x kg(-1).
Kazunori, Yamashita, Makoto, Fukusaki, Yuko, Ando, Arihiro, Fujinaga, Takahiro, Tanabe, Yoshiaki, Terao, Koji, Sumikawa   +6 more
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Flurbiprofen axetil: Analgesic effect and adverse reaction.

Pakistan journal of pharmaceutical sciences, 2019
Flurbiprofen axetil is a targeted analgesic and non steroidal analgesic with lipid microspheres as drug carrier. It can selectively accumulate in surgical incision and reduce the allodynia a caused by surgical trauma. In this paper, the experimental subjects were divided into three groups to analyze the difference in the analgesic effect of different ...
Xiaodong, Zhao, Leting, Ji
openaire   +1 more source