Results 171 to 180 of about 2,518,547 (340)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Decision letter: Neural synchronization is strongest to the spectral flux of slow music and depends on familiarity and beat salience

, 2022
Benedikt Zoefel
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Protocol for single-cell optimization objective and trade-off inference. [PDF]

STAR Protoc
Lin DW, Teixeira C, Chung C, Roy SS, Ghosh A, Chandrasekaran S.   +5 more
europepmc   +1 more source

Using zonal surface heat flux asymmetry to reveal new features of Southern Ocean air-sea interaction

, 2023
Simon A. Josey, Jeremy P. Grist, Jennifer Mecking, Ben Moat, Eric Schulz   +4 more
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Machine learning-based heat flux estimation from high-speed video during saturated pool boiling over vertical tube. [PDF]

Sci Rep
Sha BB, Thakare KV, Kar S, Dogra DP, Das MK.   +4 more
europepmc   +1 more source

Data from Elevated Methionine Flux Drives Pyroptosis Evasion in Persister Cancer Cells

, 2023
Asmaa El-Kenawi, Anders Berglund, Verónica Estrella, Yonghong Zhang, Min Liu, Ryan M. Putney, Sean Yoder, Joseph Johnson, Joel S. Brown, Robert A. Gatenby   +9 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

IGM: Integrated Gene-expression Modeling for multi-condition flux-preserving genome-scale metabolic models. [PDF]

PLoS One
Paklao T, Suratanee A, Plaimas K.
europepmc   +1 more source