Results 1 to 10 of about 14,212 (164)

Oxytocin Improves Autistic Behaviors by Positively Shifting GABA Reversal Potential via NKCC1 in Early-Postnatal-Stage. [PDF]

Adv Sci (Weinh)
New research reveals that oxytocin signaling during the early postnatal period is critical for regulating brain development and social behavior. Selectively suppressing oxytocin neurons by chemogenetic method shows that early—but not late—disruption leads to autism‐like behaviors.
Wang ZH, Xu C, Ma YY, Xue WX, Wang HY, Fan LY, Zhang CY, Li L, Zhang XY, Zhu JN, Zhang QP.   +10 more
europepmc   +2 more sources

The Fragile X Messenger Ribonucleoprotein 1 Regulates the Morphology and Maturation of Human and Rat Oligodendrocytes. [PDF]

Glia
Main Points Loss of FMRP impairs human and rat oligodendrocyte (OL) morphology in vitro. FMRP‐deficient OLs show impaired maturation when engrafted in hypomyelinated mice. Rat Fmr1 knockout OLs show a delay in myelin sheath formation in vivo. ABSTRACT The Fragile X Messenger Ribonucleoprotein (FMRP) is an RNA binding protein that regulates the ...
Ramesh V, Tsoukala E, Kougianou I, Kozic Z, Burr K, Viswanath B, Hampton D, Story D, Reddy BK, Pal R, Dando O, Kind PC, Chattarji S, Selvaraj BT, Chandran S, Zoupi L.   +15 more
europepmc   +2 more sources

Ovarian dysfunction and FMR1 alleles in a large Italian family with POF and FRAXA disorders: case report [PDF]

BMC Medical Genetics, 2007
Background The association between premature ovarian failure (POF) and the FMR1 repeat number (41> CGGn< 200) has been widely investigated. Current findings suggest that the risk estimation for POF can be calculated in the offspring of women with pre ...
D'Urso Michele, Chiurazzi Pietro, Laperuta Carmela, Miano Maria, Ursini Matilde   +4 more
doaj   +2 more sources

Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice [PDF]

Molecular Autism
Background Fragile X syndrome is caused by the loss of the Fmr1 gene expression. Deletion of Fmr1 in various neuronal and non-neuronal subpopulations in the brain of mice leads to cell-type-specific effects.
Mehdi Hooshmandi, David Ho-Tieng, Kevin C. Lister, Weihua Cai, Calvin Wong, Nicole Brown, Jonathan Fan, Volodya Hovhannisyan, Sonali Uttam, Masha Prager-Khoutorsky, Nahum Sonenberg, Christos G. Gkogkas, Arkady Khoutorsky   +12 more
doaj   +2 more sources

Prenatal Exposure to Lipopolysaccharide or Valproate Leads to Abnormal Accumulation of the NMDA Receptor Agonist D-Aspartate in the Adolescent Rat Brain. [PDF]

J Neurochem
Autism spectrum disorder (ASD) is a neurodevelopmental condition linked to glutamatergic neurotransmission abnormalities. We analyzed by HPLC the cerebral and peripheral profiles of D‐aspartate, D‐serine, and other L‐amino acids involved in NMDA receptor signaling in environmental ASD rat models prenatally exposed to lipopolysaccharide or valproate ...
Di Maio A, Yahyavi I, Buzzelli V, Motta Z, Ascone F, Putignani L, Usiello A, Pollegioni L, Trezza V, Errico F.   +9 more
europepmc   +2 more sources

Developmental Disturbances in Animal Models of Autism Spectrum Disorder. [PDF]

Dev Neurobiol
ABSTRACT Although the early signs of autism spectrum disorder (ASD) are widely studied, the significant ambiguity and heterogeneity in symptoms require the comparison of available models, approaches, and the search for common denominators and key indicators.
Laszlo K, Bacova Z, Zelena D, Bakos J.
europepmc   +2 more sources

Orchestrating Neural Development Through mRNA Translation Regulation. [PDF]

J Neurochem
This review provides an overview of mRNA translation mechanisms that control prenatal brain development, including cortical lamination, progenitor differentiation, and axon guidance, and identifies significant knowledge gaps. Specifically, we focus on mRNA translation regulation through signaling cascades such as the mammalian/mechanistic target of ...
Rodrigue B, Sajish M, Salmaso N, Aguilar-Valles A.   +3 more
europepmc   +2 more sources

FMR1 Disorders: Basics of Biology and Therapeutics in Development [PDF]

Cells
Fragile X Syndrome (FXS) presents with a constellation of phenotypes, including trouble regulating emotion and aggressive behaviors, disordered sleep, intellectual impairments, and atypical physical development. Genetic study of the X chromosome revealed
Drew A. Gillett, Helene Tigro, Yuan Wang, Zucai Suo   +3 more
doaj   +2 more sources

Development and validation of a single‐tube multiplex PCR for rapid screening of Fragile X and Fragile XE syndromes of FMR1 and FMR2 genes [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2021
Fragile X (FRAXA) syndrome and fragile XE (FRAXE) syndrome are caused by the expansion of a trinucleotide repeat in the FMR1 and FMR2 genes, respectively.
Areerat Hnoonual, Duangkamol Tangviriyapaiboon, Chariyawan Charalsawadi, Pornprot Limprasert   +3 more
doaj   +1 more source

FMR1 is identified as an immune-related novel prognostic biomarker for renal clear cell carcinoma: A bioinformatics analysis of TAZ/YAP

Mathematical Biosciences and Engineering, 2022
WW domain-containing transcription regulator 1 (TAZ, or WWTR1) and Yes-associated protein 1 (YAP) are both important effectors of the Hippo pathway and exhibit different functions.
Sufang Wu , Hua He, Jingjing Huang , Shiyao Jiang, Xiyun Deng , Jun Huang, Yuanbing Chen , Yiqun Jiang   +7 more
doaj   +1 more source