Results 171 to 180 of about 64,815 (293)

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Conversational AI Agents: The Effect of Process and Outcome Variation on Anthropomorphism and Trust

Information Systems Journal, EarlyView.
ABSTRACT Organisations increasingly deploy conversational AI agents (CAs) in agentic roles where behavioural variations are inevitable. Prior work often conflates two distinct forms of variation: outcome variation (where success fluctuates) and process variation (where the path to completion varies).
Kambiz Saffarizadeh, Mark Keil
wiley   +1 more source

Annual Research Review: Psychosis in children and adolescents: key updates from the past 2 decades on psychotic disorders, psychotic experiences, and psychosis risk

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 460-476, April 2025.
Psychosis in children and adolescents has been studied on a spectrum from (common) psychotic experiences to (rare) early‐onset schizophrenia spectrum disorders. This research review looks at the state‐of‐the‐art for research across the psychosis spectrum, from evidence on psychotic experiences in community and clinical samples of children and ...
Ian Kelleher
wiley   +1 more source

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader, Amy S. Garrett, Steven R. Pliszka   +2 more
wiley   +1 more source

Annual Research Review: Neural mechanisms of eating disorders in youth – from current theory and findings to future directions

Journal of Child Psychology and Psychiatry, EarlyView.
Eating disorders are prevalent and profoundly debilitating psychiatric conditions with multifactorial etiology that frequently manifest during adolescence. This developmental stage is characterized by significant neurostructural and neurofunctional change, which may create a context conducive to the emergence of eating pathology.
Kelsey Hagan, E. Caitlin Lloyd, Sasha Gorrell   +2 more
wiley   +1 more source

Melody transposition tolerance in the human cortex: An fMRI adaptation and MVPA investigation. [PDF]

Imaging Neurosci (Camb)
Han YA, Hsieh PJ.
europepmc   +1 more source

Annual Research Review: Early conduct problems – precursors, outcomes, and etiology

Journal of Child Psychology and Psychiatry, EarlyView.
During the toddler and preschool period, nearly all children engage in some level of aggression, defiance, stealing, and temper tantrums. While the frequency and intensity of these behaviors tends to decrease across early childhood, a subset of children engage in these conduct problem behaviors at a higher intensity early in life and/or do not desist ...
Luke W. Hyde, Christopher J. Trentacosta, Jessica L. Bezek   +2 more
wiley   +1 more source

Smartphone language and resting‐state EEG indicators of self‐focused attention prospectively predict major depressive disorder risk in adolescents

Journal of Child Psychology and Psychiatry, EarlyView.
Background Central to major depressive disorder (MDD) onset and maintenance is maladaptive self‐focused attention, which can be reliably indexed by greater: (a) usage of first‐person singular pronouns (e.g., I) in natural language and (b) alpha oscillations in resting‐state EEG.
Lilian Y. Li, Nayoung Kim, Esha Trivedi, Sarah E. Sarkas, Madeline M. McGregor, Aishwarya Sritharan, Katherine Durham, Ivan Alekseichuk, Allison M. Letkiewicz, Vijay A. Mittal, David Pagliaccio, Nicholas B. Allen, Randy P. Auerbach, Stewart A. Shankman   +13 more
wiley   +1 more source

fMRI measurements of orientation-specific contrast adaptation

NeuroImage, 2001
David Ress, David Heeger
openaire   +1 more source