Results 51 to 60 of about 82,954 (311)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Investigation of DME/DME as an Appropriate Backup for GNSS Systems in Iranian Airports [PDF]

فناوری در مهندسی هوافضا, 2020
Today, all world's aviation organizations, including ICAO, are looking for solutions to airspace shortage, growth of global air traffic, and safety of flights. Performance based navigation (PBN), which is a transition from System-Base to Performance-Base
Mohsen Kazemi, Zahra Hamidzadeh Delarzi, Mohammad Rashtian   +2 more
doaj  

The FM Agent

CoRR
Large language models (LLMs) are catalyzing the development of autonomous AI research agents for scientific and engineering discovery. We present FM Agent, a novel and general-purpose multi-agent framework that leverages a synergistic combination of LLM-based reasoning and large-scale evolutionary search to address complex real-world challenges.
Annan Li, Chufan Wu, Zengle Ge, Yee Hin Chong, Zhinan Hou, Lizhe Cao, Cheng Ju, Jianmin Wu, Huaiming Li, Haobo Zhang, Shenghao Feng, Mo Zhao, Fengzhi Qiu, Rui Yang, Mengmeng Zhang, Wenyi Zhu, Yingying Sun, Quan Sun, Shunhao Yan, Danyu Liu, Dawei Yin 0001, Dou Shen   +21 more
openaire   +2 more sources

FM-index for Dummies

, 2017
The FM-index is a celebrated compressed data structure for full-text pattern searching. After the first wave of interest in its theoretical developments, we can observe a surge of interest in practical FM-index variants in the last few years. These enhancements are often related to a bit-vector representation, augmented with an efficient rank-handling ...
Szymon Grabowski, Marcin Raniszewski, Sebastian Deorowicz   +2 more
openaire   +2 more sources

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

A control methodology for automated manufacturing [PDF]

, 1991
The application of computers in the manufacturing industry has substantially altered the control procedures used to program a whole manufacturing process. Currently, one the problems which automated manufacturing systems are experiencing is the lack of a
Nahavandi, Saeid
core  

Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop

Cell Death and Disease, 2022
Enhancement of Wnt signaling is fundamental for stem cell function during intestinal regeneration. Molecular modules control Wnt activity by regulating signal transduction. CD44 is such a positive regulator and a Wnt target gene.
Romina J. Walter, Steffen J. Sonnentag, Leonel Munoz-Sagredo, Melanie Merkel, Ludovic Richert, Felix Bunert, Yvonne M. Heneka, Thomas Loustau, Michael Hodder, Rachel A. Ridgway, Owen J. Sansom, Yves Mely, Ulrich Rothbauer, Mark Schmitt, Véronique Orian-Rousseau   +14 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

An expert system for FMS control

, 1993
High flexibility and a quick response of the flexible manufacturing system make it extremely complicated to properly control the production activities. In this paper, the complicated FMS control problem is studied.
null Zhu Jianying, Wei ZX(尉忠信), null Wang Chengen, Wang CE(王成恩), null Wei Zhongxin, Zhu JY(朱剑英)   +5 more
core   +1 more source