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FNDC5/Irisin protects neurons through Caspase3 and Bax pathways
Cell Biochemistry and FunctionIrisin is a glycosylated protein formed from the hydrolysis of fibronectin type III domain‐containing protein 5 (FNDC5). Recent studies have demonstrated that FNDC5/Irisin is involved in the regulation of glucose and lipid metabolism, it can inhibit ...
Qiuxia Zhang +4 more
semanticscholar +1 more source
MiR-143-3p/FNDC5 axis: a novel regulator of insulin sensitivity
Endocrine, 2023Insulin resistance is a key hallmark in type 2 diabetes. In recent decades, there have been numerous studies of the causes of insulin resistance. microRNAs (miRNAs) participate in the regulation of multiple aspects of energy metabolism and miR-143-3p has been shown to induce insulin resistance.
Biao Li +3 more
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Association of metabolic parameters and rs726344 in FNDC5 with serum irisin concentrations
International Journal of Obesity, 2015Irisin has been suggested as a novel myokine with beneficial effects in rodents. However, previous data in humans showed conflicting results regarding its association with metabolic phenotypes and regulation of secretion. Furthermore, although an association of rs726344 in FNDC5 (fibronectin type III domain containing 5) coding for irisin with insulin ...
T Ebert +7 more
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Auricular acupuncture induces FNDC5/irisin and attenuates obese inflammation in mice
Acupuncture in Medicine, 2020Objective: To investigate whether auricular acupuncture (AA) attenuates bodyweight and obese inflammation through the release of irisin from muscle tissue in mice. Methods: Sixty 4-week-old mice were fed a high fat diet (HFD) for 4 weeks. These animals were divided into six groups that remained untreated (HFD) or underwent electrical AA (HFD+EAA), sham
Guohua Li, Yi Lu
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Effects of Dietary Macronutrient Composition on FNDC5 and Irisin in Mice Skeletal Muscle
Metabolic Syndrome and Related Disorders, 2017Fibronectin type III domain containing 5 (FNDC5) and its protein product Irisin are therapeutic targets for obesity-associated disorders. Irisin plays an important role in energy regulation, inducing browning of white adipocytes, and improving obesity.
GuimarãesAndré Luiz Sena +10 more
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Orthopaedic Proceedings
Osteoporosis accounts for a major risk factor of fracture-associated disability or premature death in the elderly. Enhancement of bone anabolism for slowing osteoporosis is highly demanding.
Y. Lin, W. Lian, Y. Chen, F. Wang
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Osteoporosis accounts for a major risk factor of fracture-associated disability or premature death in the elderly. Enhancement of bone anabolism for slowing osteoporosis is highly demanding.
Y. Lin, W. Lian, Y. Chen, F. Wang
semanticscholar +1 more source
FNDC5 genetic polymorphism in patients with peripartum cardiomyopathy.
Caspian Journal of Internal MedicineBackground Late in pregnancy or soon after delivery, peripartum cardiomyopathy (PPCM) which is an uncommon type of cardiomyopathy, can develop. To assess the association between the level of irisin expression and (FNDC5) (rs3480) gene polymorphism with ...
A. Altaher +5 more
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Irisin/PGC-1α/FNDC5 pathway in Parkinson's disease: truth under the throes.
Naunyn-Schmiedeberg's Archives of Pharmacology, 2023Naif H. Ali +5 more
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