Public Knowledge, Attitudes, and Practices towards Antibiotic Use and Antimicrobial Resistance in Eastern Region of Bosnia and Herzegovina in the COVID-19 Pandemic [PDF]
The constant worsening of antimicrobial resistance (AMR) imposes the need for an urgent response. Use of antibiotics (AB), both due to irrational prescribing by doctors and irrational use by patients, is recognized as one of the leading causes of this ...
Dragana Drakul +8 more
doaj +2 more sources
Sitagliptin Modulates Functional and Phenotypic Properties of Human Neutrophils Under Normal- and High-Glucose Conditions In Vitro [PDF]
Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat type 2 diabetes. However, several studies have demonstrated its anti-inflammatory and immunomodulatory properties.
Vanja Mališ +8 more
doaj +2 more sources
Genetic, Sociodemographic and Clinical Determinants of COVID-19 Severity in the Republic of Srpska: Exploring Potential Links with Neanderthal-Derived Variants [PDF]
Background/Objectives: COVID-19 severity is influenced by a complex interplay between host, viral, and environmental factors. Emerging evidence suggests that Neanderthal-derived genetic variants may influence the progression and severity of SARS-CoV-2 ...
Milena Dubravac Tanasković +9 more
doaj +2 more sources
Consumption of Antibiotics in Primary Care Setting before and during COVID-19 Pandemic in Republic of Srpska, Bosnia and Herzegovina [PDF]
The pandemic of COVID-19 has brought many changes in health care systems at all levels of health care. The increase in the number of cases of COVID-19 has led to overuse and misuse of antibiotics.The aim of this study was to compare the consumption of ...
Dragana Sokolović +7 more
doaj +2 more sources
Knowledge, Attitudes, Practice, and Hesitancy of Patients and HCWs Towards COVID-19 Vaccination and Factors Associated with Vaccination in the Republic of Srpska, Bosnia and Herzegovina [PDF]
Background/Objectives: The COVID-19 pandemic caused over seven million deaths globally as of July 2024. In an attempt to bring the pandemic under control, immunization was implemented as the main preventive strategy.
Biljana Mijović +13 more
doaj +2 more sources
Efficacy and Safety of Oral Icotrokinra in Moderate-to-Severe Plaque Psoriasis: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis. [PDF]
Meta‐analysis of randomized controlled trials demonstrates that oral icotrokinra significantly improves PASI responses in patients with moderate‐to‐severe plaque psoriasis, with early clinical benefit and a placebo‐comparable safety profile, supported by trial sequential analysis confirming robust and sufficient evidence.
Altayf A +5 more
europepmc +2 more sources
Dapsone Alters Phenotypical and Functional Properties of Human Neutrophils In Vitro [PDF]
Dapsone is a sulfone used in treating inflammatory skin conditions. Despite its widespread dermatological use, the pharmacological actions of dapsone remain poorly understood.
Sara Rakočević +7 more
doaj +2 more sources
Dysfunctions of Neutrophils in the Peripheral Blood of Children with Cystic Fibrosis [PDF]
Dysfunction of neutrophils in patients with cystic fibrosis (CF) is best characterized in bronchoalveolar lavage (BAL), whereas peripheral blood neutrophils are less examined, and the results are contradictory, especially in younger populations ...
Ganimeta Bakalović +14 more
doaj +2 more sources
Efficacy and Safety of Dexmedetomidine-Esketamine Versus Dexmedetomidine Alone as Premedication for Pediatric Anesthesia Induction: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis. [PDF]
ABSTRACT Background Emergence delirium (ED) is a common complication in pediatric anesthesia. Although intranasal dexmedetomidine (DEX) is widely used, its application is constrained by a slow onset, residual risk of ED in some patients, and risks such as bradycardia and hypotension.
Lateiresh M +5 more
europepmc +2 more sources
The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis [PDF]
Background: Frequent episodes of nasal symptoms are the usual clinical manifestations (CM) of allergic rhinitis (AR) and have a significant negative impact on health-related quality of life (HRQoL) in adolescents.
Ljiljana Krsmanović +15 more
doaj +2 more sources

