Results 111 to 120 of about 120,186 (297)

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

NETRA: Interactive Display for Estimating Refractive Errors and Focal Range [PDF]

open access: yes, 2010
We introduce an interactive, portable, and inexpensive solution for estimating refractive errors in the human eye. While expensive optical devices for automatic estimation of refractive correction exist, our goal is to greatly simplify the mechanism by ...
Mohan, Ankit   +7 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Focal Mechanisms of Medium-Small Earthquakes in Taiyuan Basin Since 2016

open access: yesTaiyuan Ligong Daxue xuebao
Purposes On the basis of previous researches and the latest broadband digital waveform data from the Shanxi Regional Seismic Network, multiple methods are employed to obtain updated focal mechanism solutions for earthquakes with ML≥2.5 that occurred in ...
LI Jiali   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

PENENTUAN ORIENTASI BIDANG SESAR MENGGUNAKAN FOCAL MECHANISM HIPOSENTER GEMPA MIKRO LAPANGAN PANASBUMI “GAMMA”

open access: yes, 2014
Lapangan Panasbumi “Gamma” terletak pada jalur gunungapi yang berasosiasi dengan lapangan panasbumi lainnya dan dikontrol oleh proses geologi serta aktivitas ekploitasi panasbumi, hal tersebut diindikasikan oleh bidang sesar lokal yang menjadi salah ...
SIHOTANG, IWAN YANDIKA
core  

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

Coulomb stress effects of the April 3, 2024 Hualien, Taiwan, China MS 7.3 earthquake on the surrounding faults and subsequent April 23, 2024 MS 6.2 and MS 6.3 earthquakes

open access: yesDizhi lixue xuebao
Objective  To determine the rupture mode of the MS 7.3 earthquake in Hualien, Taiwan, China on April 3, 2024 and its triggering effect on subsequent seismic events in the surrounding area, the co-seismic displacement field and the induced areal strain ...
GU Peiyuan   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Analysis of the Intraocular Jet Flows and Pressure Gradients Induced by Air and Fluid Infusion: Mechanism of Focal Chorioretinal Damage

open access: yes, 2020
PURPOSE. To comprehend the mechanism of focal chorioretinal damage by analysis of the pressure distribution and dynamic pressure induced by infused air during fluid-air exchange. METHODS. A precise simulation featuring a model eye and a fluid circuit was
Yong Joon Kim   +4 more
core  

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