Results 121 to 130 of about 425,685 (304)
Design of a radiator shade for testing in a simulated lunar environment [PDF]
The National Aeronautics and Space Administration (NASA) and The Universities Space Research Association (USRA) have chosen the parabolic/catenary concept from their sponsored Fall 1991 lunar radiation shade project for further testing and development ...
Huff, Jaimi +2 more
core +1 more source
Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats [PDF]
, 2003 Recent experimental evidences indicate that pyruvate, the final metabolite of glycolysis, has a remarkable protective effect against different types of brain injury.
Candelario-Jalil, Eduardo +3 more
core
Comparison of solutions for microseismic focal mechanism estimation [abstract]. [PDF]
Geology, Geophysics & Environment, 2016 Paweł Wandycz +2 more
openaire +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Biomimetic and Biophysical Approach to Profile Metastatic Cancer Cell Migration [PDF]
, 2018 Honors Research ScholarshipCancer metastasis is a complex process by which cells in a primary tumor acquire an aggressive phenotype, and travel to distant, secondary sites in the body.
Enders, Jacob
core
Automatic Determination of Focal Mechanism Solution Using Initial Motion Polarity of P Waves.
Papers in Meteorology and Geophysics, 2002 自動的に、P波の初動極性を取得し、発震機構解を決定し、十分な精度で発震機構解が決定できているか否かを判別する手法を提案した。P波の初動極性を取得する際には、まず、ベッセルバンドパスフィルタを適用し、次に、ARモデルを用いてP波の初動到達時を得、ARフィルタを適用した。発震機構解の決定には、グリッドサーチによる手法を用いた。十分な精度で発震機構解が決定できているか否かを判別するために、解の安定性、過去に発生した地震の発震機構解等から総合的に判断し、発震機構解の決定精度の評価を行った。気象庁によって読みとられた初動極性の70%が、本手法を適用することによって得られた。また、両者でくい違った験測を行っているのは全体の3.5%以下であり、十分な精度で初動極性の自動験測が行われた。さらに ...
openaire +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Steric regulation of tandem calponin homology domain actin-binding affinity. [PDF]
, 2019 Tandem calponin homology (CH1-CH2) domains are common actin-binding domains in proteins that interact with and organize the actin cytoskeleton. Despite regions of high sequence similarity, CH1-CH2 domains can have remarkably different actin-binding ...
Bausch, Andreas +6 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source