Results 211 to 220 of about 119,596 (257)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Investigations into linker effects of DNA-VHL ligand conjugates by multiplexed affinity measurements using focal molography. [PDF]

RSC Chem Biol
Raschke P, Notova S, Gatterdam V, Frutiger A, Brunschweiger A.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Background selection in recombining genomes and its consequences for the maintenance of variation in complex traits. [PDF]

Proc Natl Acad Sci U S A
Li X, Berg JJ.
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Intelligent high-throughput recognition model for bitter gourd fruit morphology and tubercle characteristics. [PDF]

Sci Rep
Liu S, Cai Y, Xu H, Deng Y, Zhong X, Tian J, Bai F, Lu J, Lin Z, Zhang F, Ruan M, Li H, Huang Z, Zhu C, Zhong F.   +14 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Gain Curves, Reproductive Efficiency, and Sex Allocation. [PDF]

Ecol Evol
Burd M.
europepmc   +1 more source

Seismological analysis of the tectonic evolution of the Laji Shan fault from the 2023 Jishishan MS 6.2 earthquake. [PDF]

Sci Rep
Xie Z.
europepmc   +1 more source

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Focal mechanism solutions for roof collapse in deep mine

International Journal of Mining and Mineral Engineering, 2015
Microseismic monitoring is an effective means of forecasting instabilities in ruptured rock masses during deep mining. Based on the complex geological conditions of a mine in Southwest China, a digital 24–channel microseismic monitoring system was established to monitor microseismic events during deep mining.
Chun lai Wang, Hui Fu, Fu li Wang, Wei qiang Li, Ming Luo, Lu Liu, Zhi jiang Lu, Ai xiang Wu, Xiao hui Liu   +8 more
openaire   +1 more source