Results 121 to 130 of about 6,474,936 (293)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Determination of Earthquake Focal Mechanism Using Artificial Intelligence

Focal mechanism solution is important to analyze faulting type, fault geometry, and to evaluate aftershock patterns after a devastating earthquake occurs.
GÖK, ELÇİN, ŞENOL, YAVUZ, Kalkar, Berkay, KAFTAN, İLKNUR   +3 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

On Maskin monotonicity of solution based social choice rules [PDF]

, 2007
Haake C-J, Trockel W. On Maskin monotonicity of solution based social choice rules. Working Papers. Institute of Mathematical Economics. Vol 393. Bielefeld: Universität Bielefeld; 2007.Howard (1992) argues that the Nash bargaining solution is not Nash ...
Haake, Claus-Jochen, Trockel, Walter, Trockel, Walter ; https://orcid.org/   +2 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

QUICK DETERMINATION OF THE FAULT MECHANISM FROM INITIAL P-WAVE AMPLITUDE DISTRIBUTION

, 2018
When an earthquake occurs, there are only few seconds between the rupture beginning and its devastating effect on population and buildings. Having a reliable image of the seismic source in real-time is crucial for producing realistic strong motion shake ...
Tarantino Stefania, Zollo Aldo, Emolo Antonio, Colombelli Simona   +3 more
core  

Focal Mechanisms of Medium-Small Earthquakes in Taiyuan Basin Since 2016

Taiyuan Ligong Daxue xuebao
Purposes On the basis of previous researches and the latest broadband digital waveform data from the Shanxi Regional Seismic Network, multiple methods are employed to obtain updated focal mechanism solutions for earthquakes with ML≥2.5 that occurred in ...
LI Jiali, LI Bin, JIN Yidan, ZHAO Xiaoyun, LI Zihong   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source