Results 231 to 240 of about 6,474,936 (293)

Histopathology of skeletal dysplasia in a Japanese Black calf with marked epiphyseal enlargement. [PDF]

J Vet Med Sci
Nakamura T, Iwata A, Ikezawa M, Tsuji R, Takamura Y, Inagaki K, Masuda T, Hishikawa S, Sunden Y.   +8 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Hybrid Z‑scan simultaneously probes nonlinear absorption and fluorescence competition in xanthene dye systems with plasmonic nanoparticles. [PDF]

Discov Nano
Sharifi S.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Steering root-associated microbiomes via direct and soil legacy effects of neighbors. [PDF]

Microbiome
Kuerban M, Gomes SIF, Erol O, Bezemer TM.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Non-elastic membrane dual-actuation liquid lens for continuous focus and zoom. [PDF]

Microsyst Nanoeng
Zhang J, Zhang WX, Shen H, Lu Y, Jin YX, Liu YZ, Chen GY, Wu H, Xue LW, Sun LN, Chen LG.   +10 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Acoustically Activatable Drug-Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors. [PDF]

Adv Sci (Weinh)
Bercovici T, Bismuth M, Goldsmith M, Peer D, Ilovitsh T.   +4 more
europepmc   +1 more source

RBM39 upregulation promotes ostium re-obstruction after endoscopic endonasal dacryocystorhinostomy (En-DCR). [PDF]

BMC Mol Cell Biol
Liu J, Zhao J, Zhu X, Liu X, Zhu L, Lin T.   +5 more
europepmc   +1 more source