Results 151 to 160 of about 14,099,511 (342)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
“Coming Out of My Shell”: Motherleaders Contesting Fear, Vulnerability, and Despair through Family-focused Community Organizing [PDF]
Jennifer E. Cossyleon
openalex +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Low-intensity focused ultrasound to the posterior insula reduces temporal summation of pain [PDF]
Alexander In +3 more
openalex +1 more source
[From the Introduction]\ud \ud Focus groups are a very commonly used method in health research and appear to be both highly accessible and amenable to addressing a broad range of topics. However, this masks some of the subtleties involved and the apparent ease with which focus groups can be employed has sometimes led to lazy and uncritical use ...
openaire +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
The Best of Both Worlds: Combining Label Free and Fluorescence Imaging with Livecyte [PDF]
Djali Peter, Jotangia Meetal
doaj +1 more source

