Results 171 to 180 of about 16,535,822 (307)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Reflective Learning from Do Not Intubate/Do Not Resuscitate Conversations: A Qualitative Study Using Gibbs Reflective Methodology and Focus Group Discussion. [PDF]

Indian J Palliat Care
Abraham BM, Geo R, Chittazhathu RK, Nair S.   +3 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Human Papillomavirus (HPV) Vaccination and Cervical Cancer Prevention: Ghanaian Adolescent Students' Perspectives Through Focus Group Discussion. [PDF]

Asian Pac J Cancer Prev
Abrefah E, Agyei-Baffour P, Owusu AB, Commeh ME, Koranteng A, Elizondo AC, Asare M.   +6 more
europepmc   +1 more source

Bus Workers' Experiences with and Perceptions of a Health Promotion Program: A Qualitative Study Using a Focus Group Discussion. [PDF]

Int J Environ Res Public Health, 2020
Pyo J, Lee M, Ock M, Park G, Yang D, Park J, Kim Y.   +6 more
europepmc   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Identification of knowledge, behavior and health application needs for cardiovascular disease prevention in young women: An interview and focus group discussion study in Makassar city. [PDF]

J Educ Health Promot
Rachman I, Maria IL, Wahiduddin W, Mappangara I, Jafar N, Riskiyani S, Irwandy I.   +6 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Multistakeholder scientific advice for medicinal products used in combination with a medical device or a companion diagnostic in the EU-summary of a Focus group discussion. [PDF]

Front Med (Lausanne)
Aarum S, Popp C, Hunter A, Skvarc M, Reischl I, Zander H, Zinserling J, van Leeuwen P, Sutch J, Chesworth T, Kapeller E, Emmendoerffer A, Gravanis I, Bouygues C, Vincenzi C, Berntgen M.   +15 more
europepmc   +1 more source

Gridlock from diagnosis to treatment of multidrug resistant tuberculosis (MDR-TB) in Tanzania: patients' perspectives from a focus group discussion. [PDF]

BMC Public Health, 2020
Mpagama SG, Ezekiel MJ, Mbelele PM, Chongolo AM, Kibiki GS, de Guex KP, Heysell SK.   +6 more
europepmc   +1 more source