Results 201 to 210 of about 17,191,473 (306)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Challenges and Alternatives to Evaluation Methods and Regulation Approaches for Medical Apps as Mobile Medical Devices: International and Multidisciplinary Focus Group Discussion. [PDF]

J Med Internet Res
Maaß L, Hrynyschyn R, Lange M, Löwe A, Burdenski K, Butten K, Vorberg S, Hachem M, Gorga A, Grieco V, Restivo V, Vella G, Varnfield M, Holl F.   +13 more
europepmc   +1 more source

Report on focus group discussions

This report summarizes the coding manual and the outcome (e.g., transcripts) of focus groups.
openaire   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Clinical implementation of advanced respiratory monitoring with esophageal pressure and electrical impedance tomography: results from an international survey and focus group discussion. [PDF]

Intensive Care Med Exp
Wisse JJ, Scaramuzzo G, Pellegrini M, Heunks L, Piraino T, Somhorst P, Brochard L, Mauri T, Ista E, Jonkman AH.   +9 more
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Are boarding secondary schools suitable for students with asthma? An asynchronous online focus group discussion among members of an asthma awareness group. [PDF]

PLoS One
Amorha KC, Ochie KM, Ogbodo SC, Akunne OZ, Obi OC, Ene NT, Ifeanyi CR, Ikokwu J, Eze CV, Ogbonna ET, Chukwu MI, Okafor CC, Echeta CR, Nwani SP, Okoye CO, Okonkwo VC, Eneje CJ, Ozota GO.   +17 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impact of vision problems on children's daily activities: Insights from a focus group discussion. [PDF]

F1000Res
Magakwe TSS, Hansraj R, Xulu-Kasaba ZN.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source