Results 91 to 100 of about 350,383 (340)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Design, Analysis, and Manufacturing of Diffractive Achromatic Optical Systems
MicromachinesThe increasing resolution requirements of imaging optical systems must be satisfied by expanding the aperture of the optical system according to Rayleigh’s criterion, and larger apertures of conventional refractive/reflective optics place a greater ...
Yidi Zheng +5 more
doaj +1 more source
Time-dependent two-level models and zero-area pulses
, 2015 Time-dependent two-level models have been an important element in physics, and in particular in quantum optics since 1930's. We review the basics of these models and focus on the dynamics induced by off-resonant zero-area pulses by using a Sech-Tanh ...
Lehto, Jaakko, Suominen, Kalle-Antti
core +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Wavefront analysis and phase correctors design using SHADOW
Journal of Synchrotron RadiationKnife-edge imaging is a successful method for determining the wavefront distortion of focusing optics such as Kirkpatrick–Baez mirrors or compound refractive lenses.
Hossein Khosroabadi +3 more
doaj +1 more source
Extended Dual-Focus Microscopy for Ratiometric-Based 3D Movement Tracking
Applied Sciences, 2020 Imaging the three-dimensional movement of small organelles in living cells can provide key information for the dynamics of drug delivery and virus transmission in biomedical disciplines.
Seohyun Lee, Hyuno Kim, Hideo Higuchi
doaj +1 more source
, 2015 In this work, we propose the generation of diffraction resistant beams by using a parabolic reflector and a source of spherical waves positioned at a point slightly displaced from its focus (away from the reflector).
Ambrosio, Leonardo A. +2 more
core +1 more source
Focus issue introduction: Nonlinear optics 2013
Optics Express, 2013 Nonlinear Optics has continued to develop over the last few years at an extremely fast pace, with significant advances being reported in nonlinear optical metamaterials, optical signal processing, quantum optics, nonlinear optics at subwavelength scale, and biophotonics.
Jerry I. Dadap +2 more
openaire +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Focus on Cloaking and Transformation Optics
New Journal of Physics, 2008 'Any sufficiently advanced technology is indistinguishable from magic', as the late Arthur C Clarke wrote. So what does it take to do magic by technology? Transformation optics has developed some tantalizing ideas and the first practical demonstrations of 'pure and applied magic'. Transformation optics gathers an unusual mix of scientists, ranging from
Ulf Leonhardt, David R Smith
openaire +1 more source