Results 11 to 20 of about 8,775,802 (328)

Current State of Potential Mechanisms Supporting Low Intensity Focused Ultrasound for Neuromodulation

Frontiers in Human Neuroscience, 2022
Low intensity focused ultrasound (LIFU) has been gaining traction as a non-invasive neuromodulation technology due to its superior spatial specificity relative to transcranial electrical/magnetic stimulation.
John Dell'Italia, Joseph L. Sanguinetti, Joseph L. Sanguinetti, Martin M. Monti, Martin M. Monti, Martin M. Monti, Alexander Bystritsky, Alexander Bystritsky, Nicco Reggente, Nicco Reggente   +9 more
doaj   +2 more sources

Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification

Nature Communications, 2022
Ultrasonic neuromodulation has the unique potential to provide non-invasive control of neural activity in deep brain regions with high spatial precision and without chemical or genetic modification.
Sangjin Yoo, D. Mittelstein, Robert C. Hurt, Jérôme J. Lacroix, Mikhail G. Shapiro   +4 more
semanticscholar   +1 more source

Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson's Disease.

New England Journal of Medicine, 2023
BACKGROUND Unilateral focused ultrasound ablation of the internal segment of globus pallidus has reduced motor symptoms of Parkinson's disease in open-label studies.
V. Krishna, P. Fishman, H. Eisenberg, M. Kaplitt, G. Baltuch, J. Chang, Wei-Chieh Chang, R. Martínez Fernández, Marta Del Álamo, C. Halpern, P. Ghanouni, R. Eleopra, Rees G. Cosgrove, J. Guridi, R. Gwinn, Pravin Khemani, A. Lozano, N. McDannold, A. Fasano, M. Constantinescu, I. Schlesinger, Arif Dalvi, W. Elias   +22 more
semanticscholar   +1 more source

Spatiotemporal control of engineered bacteria to express interferon-γ by focused ultrasound for tumor immunotherapy

Nature Communications, 2022
Bacteria-based tumor therapy has recently attracted wide attentions due to its unique capability in targeting tumors and preferentially colonizing the core area of the tumor.
Yuhao Chen, Meng Du, Zhen Yuan, Zhiyi Chen, Fei Yan   +4 more
semanticscholar   +1 more source

Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation

Nature Communications, 2021
Transcranial focused ultrasound (tFUS) is a promising neuromodulation technique, but its mechanisms remain unclear. We hypothesize that if tFUS parameters exhibit distinct modulation effects in different neuron populations, then the mechanism can be ...
Kai Yu, Xiaodan Niu, E. Krook-Magnuson, Bin He   +3 more
semanticscholar   +1 more source

Blood-brain barrier opening with focused ultrasound in Parkinson’s disease dementia

Nature Communications, 2021
MR-guided focused ultrasound (MRgFUS), in combination with intravenous microbubble administration, has been applied for focal temporary BBB opening in patients with neurodegenerative disorders and brain tumors.
Carmen Gasca-Salas, Beatriz Fernández-Rodríguez, J. Pineda-Pardo, R. Rodríguez-Rojas, I. Obeso, Frida Hernández-Fernández, Marta Del Álamo, David Mata, P. Guida, C. Ordás-Bandera, J. I. Montero-Roblas, R. Martínez-Fernández, G. Foffani, Itay Rachmilevitch, J. Obeso   +14 more
semanticscholar   +1 more source

Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision [PDF]

Light: Science & Applications, 2022
High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological diseases. Current non-invasive neuromodulation methods offer limited precision at the millimeter level.
Yueming Li, Ying Jiang, L. Lan, Xiaowei Ge, Ran Cheng, Yuewei Zhan, Guo Chen, Linli Shi, Runyu Wang, Nan Zheng, Chen Yang, Ji-Xin Cheng   +11 more
semanticscholar   +1 more source

Comparison between MR and CT imaging used to correct for skull-induced phase aberrations during transcranial focused ultrasound

Scientific Reports, 2022
Transcranial focused ultrasound with the InSightec Exablate system uses thermal ablation for the treatment of movement and mood disorders and blood brain barrier disruption for tumor therapy.
Steven A. Leung, David Moore, Yekaterina Gilbo, John Snell, Taylor D. Webb, Craig H. Meyer, G. Wilson Miller, Pejman Ghanouni, Kim Butts Pauly   +8 more
doaj   +1 more source

Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors

Science Advances, 2021
Focused ultrasound transiently opens the blood-brain barrier and provides the potential to modulate tumor immunostimulatory effect. Focused ultrasound (FUS) in the presence of microbubbles can transiently open the blood-brain barrier (BBB) to increase ...
Ko-Ting Chen, W. Chai, Ya-Jui Lin, Chia-Jung Lin, Pin-Yuan Chen, H. Tsai, Chiung-Yin Huang, J. Kuo, Hao-Li Liu, Kuo-Chen Wei   +9 more
semanticscholar   +1 more source

A tool for monitoring cell type–specific focused ultrasound neuromodulation and control of chronic epilepsy

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Ultrasound can be focused through skull onto the deep brain, altering neural activity noninvasively. Despite its broad utility, the action of focused ultrasound on specific cell types is almost entirely unknown.
Keith R. Murphy, Jordan S. Farrell, Juan L. Gomez, Quintin Stedman, Ningrui Li, S. Leung, C. Good, Z. Qiu, K. Firouzi, K. Butts Pauly, B. Khuri-Yakub, M. Michaelides, I. Soltesz, L. de Lecea   +13 more
semanticscholar   +1 more source