Results 181 to 190 of about 1,837,575 (292)
Letter to the Editor concerning Takeda M, Koga H, Lane GJ, Tanaka N, Nagakawa Y, Okazaki T, Urao M,Yamataka A. Historical aspects of anatomic landmarks during pull-through for hirschsprung disease: focusing on resection levels of the aganglionic rectum and rectal cuff issues. Pediatr Surg Int. 2025 Nov 17;42(1):14. [PDF]
Wilms M, Mohideen M, Neumayr M, Lemli A.
europepmc +1 more source
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Self-trapping and skin solitons in two-dimensional non-Hermitian lattices. [PDF]
Kokkinakis ET, Komis I, Makris KG.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Welcoming 2026: Broadening Clinical Perspectives. [PDF]
Pae CU.
europepmc +1 more source
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Using copper-foil explosions to generate underwater focusing shocks of different geometries. [PDF]
Rojas Mata S +2 more
europepmc +1 more source

