Results 221 to 230 of about 2,959,227 (291)

Spatiotemporal shaping of terahertz radiation produced by a two-color ultrashort flying focus. [PDF]

Nat Commun
Pigeon JJ, Markland HS, Boni R, Miller KG, Elliott AL, Kendrick J, Lim Pac Chong M, Estrela P, Gitlin DJ, Purschke DN, Palastro JP, Froula DH.   +11 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Reframing continuity of care: A family medicine specialist's perspective on occupational therapy for neurodevelopmental disorders. [PDF]

Malays Fam Physician
Ismail S.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Underdiagnosis of Health: A Key Driver of Overdiagnosis of Disease. [PDF]

J Eval Clin Pract
Hofmann B.
europepmc   +1 more source

Red Blood Cells as Endogenous Biotweezers for Optical Micromanipulation In Vivo. [PDF]

Adv Sci (Weinh)
Yang T, Ren X, Ma D, Pang H, Chen W, Cai K, Yuan M, Zhang B, Lin Z, Liu X.   +9 more
europepmc   +1 more source

3D printing monolithic, multifunctional polymer acoustofluidic devices with tunable mixing and particle focusing.

Lab Chip
Balanay RK, Yip JW, Do J, Adil O, Johnson K, Ray TR.   +5 more
europepmc   +1 more source

Laser Ultrasonic Detection and Signal Enhancement of Internal Microdefects in LPBF Ti6Al4V with Anisotropic Microstructure: Simulations and Experiments. [PDF]

Micromachines (Basel)
Zhou X, Xie J, He Y, Hu P.
europepmc   +1 more source