Results 71 to 80 of about 99,743 (309)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Temporality, Reproduction and the Not-Yet in Denis Villeneuve's Arrival

Film-Philosophy, 2018
The prolepsis in Denis Villeneuve's Arrival emphasises the cyclical nature of the film's narrative and anchors human reproduction as a central theme. Pregnancy, the pregnant body, and the physical, experiential nature of birth, commonly heavily gendered ...
Anne Carruthers
doaj   +1 more source

Harlequin foetus.

Journal of Postgraduate Medicine, 2003
We report a male with harlequin foetus (HF) a product of consanguineous union. The maternal age was 37 years and paternal age was 42 years. This baby born at 29 weeks of gestation was weighing 1300g at birth. He died 15 hours after birth.
S. Bianca, C. Ingegnosi, F. Bonaffini
openaire   +2 more sources

Detection of high levels of congenital transmission of toxoplasma gondii in natural urban populations of mus domesticus [PDF]

, 2004
The relative importance of different transmission routes of Toxoplasma gondii has been a matter for debate. This ubiquitous parasite is generally thought to be transmitted by infective oocysts excreted by the definitive host, the cat.
Hide, G, Hughes, JM, Marshall, PA, Murphy, G, Murphy, RG, Smith, JE, Williams, RH   +6 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Invited review: impact of specific nutrient interventions during mid-to-late gestation on physiological traits important for survival of multiple-born lambs

Animal, 2017
To improve production efficiency, the sheep meat industry has increased flock prolificacy. However, multiple-born lambs have lower birth weights, increased mortality and reduced growth rate compared with single-born lambs. Lamb mortality is a major issue
S.A. McCoard, F.A. Sales, Q.L. Sciascia
doaj   +1 more source

Acute maternal exercise during the third trimester of pregnancy, influence on foetal heart rate = Ejercicio físico durante el tercer trimestre de embarazo, influencia en la frecuencia cardiaca fetal [PDF]

, 2008
A substantial amount of research has investigated the influence of physical exercise during pregnancy on certain maternal and foetal parameters. Regarding the behaviour of the foetal heart rate (FHR) during the maternal exercise certain controversy ...
Barakat Carballo, Ruben, Lucía Mulas, Alejandro, Stirling, James, Zakynthinaki, María S.   +3 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The four-dimensional ultrasonography effects on changes of foetal and maternal heart rate: Are these interventions safe?

Advances in Human Biology, 2018
Background and Objectives: Ultrasonography is one of the prenatal diagnostic methods, which is applied to detect any genetic diseases, defects, and anomalies. This study aimed to evaluate the changes in foetal heart rate (FHR) and maternal heart rate due
Mahdis Naafe, Fatemeh Saafi, Hormoz Haddad Larijani, Mehri Jamilian, Bahman Sadeghi, Abolfazl Mohammadbeigi   +5 more
doaj   +1 more source