Results 61 to 70 of about 4,456,949 (292)

Protein folding [PDF]

Journal of Cellular and Molecular Medicine, 2003
AbstractThe problem of protein folding is that how proteins acquire their native unique three‐dimensional structure in the physiological milieu. To solve the problem, the following key questions should be answered: do proteins fold co‐ or post‐translationally, i.e.
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

POST-ANTROPOCENTRIC HYPOSUBJECTIVATION

Вісник Харківського національного університету імені В.Н. Каразіна. Серія Філософія, філософські перипетії, 2018
The article considers hyposubjectivation as the most essential kind of subjectivation in a post-Antropocentric context. Hyposubjectivation is a variety of subjectivation that takes into account the possibility and necessity of anthropological nothing or ...
Nataliia V. Zahurska
doaj   +1 more source

Cobordisms of fold maps and maps with prescribed number of cusps

, 2007
A generic smooth map of a closed $2k$-manifold into $(3k-1)$-space has a finite number of cusps ($\Sigma^{1,1}$-singularities). We determine the possible numbers of cusps of such maps.
Ekholm, Tobias, Szucs, Andras, Terpai, Tamas   +2 more
core   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Fold Lens Flux Anomalies: A Geometric Approach

, 2010
We develop a new approach for studying flux anomalies in quadruply-imaged fold lens systems. We show that in the absence of substructure, microlensing, or differential absorption, the expected flux ratios of a fold pair can be tightly constrained using ...
Angonin-Willaime, Chartas, Chiba, Dalal, David M. Goldberg, Fassnacht, Fassnacht, Goldberg, Gordon T. Richards, Holder, Impey, Inada, Katz, Keeton, Keeton, Keeton, Keeton, Keeton, Keeton, King, Kochanek, Koopmans, Marlow, Mary K. Chessey, Metcalf, Morgan, Muñoz, Myers, Petters, Pooley, Pooley, Schechter, Schneider, Snellen, Wendy B. Harris, Williams   +35 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Age‐dependent treatment effect of vocal fold steroid injection for benign vocal fold lesions

Laryngoscope Investigative Otolaryngology, 2023
Objective Benign vocal fold lesions (BVFLs) cause voice disorders and impair social life. Recently, office‐based vocal fold steroid injection (VFSI) has gained attention as a minimally invasive treatment for BVFLs.
Miki Nozawa, Takeharu Kanazawa, Kazuya Kurakami, Kazutaka Kashima, Ayako Okui, Tomohiro Hasegawa, Mayu Hirosaki, Manami Kamitomai, Takeshi Igarashi, Makoto Ito, Yusuke Watanabe   +10 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source