Results 71 to 80 of about 4,456,949 (292)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
A classification of special 2-fold coverings
, 2008 Starting with an O(2)-principal fibration over a closed oriented surface F_g, g>=1, a 2-fold covering of the total space is said to be special when the monodromy sends the fiber SO(2) = S^1 to the nontrivial element of Z_2.
Bauval, Anne +3 more
core +3 more sources
Cotranslational Folding Increases GFP Folding Yield [PDF]
Biophysical Journal, 2010 Protein sequences evolved to fold in cells, including cotranslational folding of nascent polypeptide chains during their synthesis by the ribosome. The vectorial (N- to C-terminal) nature of cotranslational folding constrains the conformations of the nascent polypeptide chain in a manner not experienced by full-length chains diluted out of denaturant ...
Ugrinov, Krastyu G., Clark, Patricia L.
openaire +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
A new 5-fold flop and derived equivalence
, 2016 We describe a new example of a flop in 5-dimensions, due to Roland Abuaf, with the nice feature that the contracting loci on either side are not isomorphic. We prove that the two sides are derived equivalent.Comment: v1.
Segal, Ed
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
The Fold as a Design Strategy: Analogy between Architecture and Issey Miyake’s Work
ArtsThere is a notable similarity between the objectives of Architecture and Fashion Design. Both disciplines aim to protect and establish a sense of identity for their users. Similarly, analogous design strategies may be employed.
Marta Muñoz, Ángel Cordero
doaj +1 more source
Biomolecules, 2020 The model of protein folding proposed by Ptitsyn and colleagues involves the accretion of secondary structures around a nucleus. As developed by Efimov, this model also provides a useful way to view the relationships among structures.
William R. Taylor
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source