Results 91 to 100 of about 792,223 (273)
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Communications, Faculty Of Science, University of Ankara Series A1Mathematics and Statistics, 1986 Suppose M n and N n are manifolds without boundary, and \(f: M\to N\) is continuous. Say that f is a topological folding if for each \(x\in M\) there are charts \(\phi: B^ n\to M\) and \(\psi=B^ n\to N\) such that \(\phi(0)=x\), \(\psi(0)=f(x)\), and a topological folding \(g: S^{n-1}\to S^{n-1}\) such that \(\psi\hat g=f\phi\), where \(\hat g: B^ n\to
Robertson, S. A., Elkholy, E.
openaire +3 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Thermodynamics and Kinetics of Folding of a Small Peptide
, 2001 We study the thermodynamics and kinetics of folding for a small peptide. Our data rely on Monte Carlo simulations where the interactions among all atoms are taken into account.
Hansmann, Ulrich H. E., Onuchic, Jose N.
core +2 more sources
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Distance-based Protein Folding Powered by Deep Learning
, 2018 Contact-assisted protein folding has made very good progress, but two challenges remain. One is accurate contact prediction for proteins lack of many sequence homologs and the other is that time-consuming folding simulation is often needed to predict ...
Xu, Jinbo
core
Computational Studies of Protein Folding [PDF]
, 2012 Proteins are known to fold into tertiary structures that determine their functionality in living organisms. The goal of our research is to better understand the protein folding process.
Cleland, Andrew, Wisthoff, Addison
core +1 more source
Periodic force induced stabilization or destabilization of the denatured state of a protein
, 2012 We have studied the effects of an external sinusoidal force in protein folding kinetics. The externally applied force field acts on the each amino acid residues of polypeptide chains.
Bidhan Chandra Bag +4 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Cathepsin B prevents cell death by fragmentation and destruction of pathological amyloid fibrils
Cell Death DiscoveryAmyloid fibrils cause organ and tissue dysfunction in numerous severe diseases. Despite the prevalence and severity of amyloidoses, there is still no effective and safe anti-amyloid therapy.
Maksim I. Sulatsky +4 more
doaj +1 more source