Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin +11 more
wiley +1 more source
Dermoscopy of Lichen Planus Follicularis Tumidus: A Case Report With Pattern Analysis and Literature Review. [PDF]
Azhari V, Saber M.
europepmc +1 more source
Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle +26 more
wiley +1 more source
Pancreatic Lymphoepithelial Cyst With High ¹⁸F-Fluorodeoxyglucose (FDG) Uptake Mimicking Malignancy: A Case Report and Literature Review. [PDF]
Takahashi K +9 more
europepmc +1 more source
Scrotal Abscess Mimicking Fixed Drug Eruption Under Ibuprofen Therapy: A Diagnostic Pitfall
ABSTRACT Concurrent NSAID therapy can pharmacologically mask early scrotal abscess, generating a presentation that fulfills clinical and historical criteria for fixed drug eruption. Ibuprofen simultaneously acts as a recognized causative agent and suppresses infectious inflammatory signs.
Youssef Maachi +6 more
wiley +1 more source
Synchronous Haemorrhagic Tumors of the Anterior Maxilla and Oropharynx
Photomicrograph of a low‐power view of partially ulcerated squamous mucosa with underlying vascular proliferation showing anastomosing vascular channels. Hematoxylin and eosin stain. Magnification ×20. ABSTRACT Oral epithelioid angiosarcoma arising in the oral cavity is exceptionally rare.
Brian Maloney +5 more
wiley +1 more source
Torsion of a Luteal Cyst at 36 Weeks of Gestation: A Case Report. [PDF]
Machavariani P +11 more
europepmc +1 more source
Malignant Proliferating Trichilemmal Tumor: A Rare Case Report and Review of Literature
ABSTRACT This case shows the rarity of Malignant Proliferating Trichilemmal Tumor (MPTT) as well as its aggressive behavior as an adnexal tumor with metastatic potential, requiring early diagnosis and excision. MPTT may occur in younger patients and at atypical sites; malignant transformation should be suspected in long‐standing trichilemmal lesions ...
Chanda Shrestha +5 more
wiley +1 more source

