Results 51 to 60 of about 1,105,411 (349)

Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota

open access: yesAdvanced Science, EarlyView.
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo   +11 more
wiley   +1 more source

The runaway instability of thick discs around black holes. I. The constant angular momentum case

open access: yes, 2002
We present results from a numerical study of the runaway instability of thick discs around black holes. This instability is an important issue for most models of cosmic gamma-ray bursts, where the central engine responsible for the initial energy release
Daigne, Frederic, Font, Jose A.
core   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

open access: yesAdvanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang   +11 more
wiley   +1 more source

Monetary reform in times of Charles II (1679-1686): aspects concerning the issued dispositions [PDF]

open access: yes, 2006
During the reign of Carlos II drastic monetary reform was carried out, which once and for all ended the tremendous monetary instability that took place in Castile throughout the whole Seventeenth century.
Font de Villanueva, Cecilia
core   +1 more source

Non-axisymmetric relativistic Bondi-Hoyle accretion onto a Schwarzschild black hole [PDF]

open access: yes, 1998
We present the results of an exhaustive numerical study of fully relativistic non-axisymmetric Bondi-Hoyle accretion onto a moving Schwarzschild black hole.
Font, Jose A., Ibanez, Jose M.
core   +2 more sources

Autopolyploidization‐Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa

open access: yesAdvanced Science, EarlyView.
This study demonstrates that monoploid, diploid, and autotetraploid Brassica rapa lines derived from the same genome exhibit distinct leaf morphology. Ploidy changes remodel chromatin accessibility and histone modifications to regulate gene expression, while key transcription factors BrGRF13 and BrARF11 control leaf size and polarity, driving ...
Haoyuan Dong   +17 more
wiley   +1 more source

Evolution of glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes

open access: yesСахарный диабет, 2017
Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are a class of antidiabetic drugs developed over the past 15 years. GLP-1, a gastrointestinal peptide hormone that contributes to the postprandial “incretin effect”, stimulates ...
Gagik R. Galstyan   +2 more
doaj   +1 more source

SUSY-breaking Soft Terms in a MSSM Magnetized D7-brane Model

open access: yes, 2004
We compute the SUSY-breaking soft terms in a magnetized D7-brane model with MSSM-like spectrum, under the general assumption of non-vanishing auxiliary fields of the dilaton and Kahler moduli.
Font, A., Ibanez, L. E.
core   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

open access: yesAdvanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li   +3 more
wiley   +1 more source

Realtà latina e mongola in conflitto. L’esperienza odeporica di Guglielmo di Rubruck (1253-1255)

open access: yesPeloro
Dopo l’invasione mongola dell’Occidente latino, la sede apostolica e i sovrani occidentali guardarono con attenzione all’Asia e alcuni inviarono presso i mongoli legati e ambasciatori. Le prime relazioni furono animate da un clima di opposizione, causato
Giovanni Di Bella
doaj   +1 more source

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