Results 91 to 100 of about 14,402 (270)

Subdiaphragmatic venous hemodynamics in the Fontan circulation [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2001
We investigated the subdiaphragmatic venous physiology in patients subjected to the Fontan operation to understand some of the early and late problems of this circulation.Flows were evaluated by Doppler ultrasonography in the subhepatic inferior vena cava, hepatic vein, and portal vein during respiratory monitoring and with a tilt table. Twenty control
T. Hsia, S. Khambadkone, J. Deanfield, J. Taylor, MIGLIAVACCA, FRANCESCO, M. De Leval   +5 more
openaire   +3 more sources

Physics‐Informed Emulation of Systemic Circulation for Fast Parameter Estimation and Uncertainty Quantification

International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 2, February 2026.
This work presents an innovative approach to modelling 1D fluid dynamics in complex networks using physics‐informed neural networks as surrogate models. By integrating physics‐based constraints with data‐driven learning, we develop an efficient and generalisable framework for uncertainty quantification and parameter estimation in real‐world ...
William Ryan, Alyssa Taylor‐LaPole, Mette Olufsen, Dirk Husmeier, Vladislav Vyshemirskiy   +4 more
wiley   +1 more source

Complications à moyen et long terme des opérations de Fontan pour les coeurs univentriculaires [PDF]

, 2014
Les ventricules uniques sont des malformations cardiaques que l'on classifie selon la morphologie du ventricule et du type de connexion atrioventriculaire. Un traitement chirurgical est nécessaire pour la survie des patients : seulement 50% des patients
ROCH, L.
core  

A One‐Dimensional (1D) Computational Fluid Dynamics Study of Fontan‐Associated Liver Disease (FALD)

International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 1, January 2026.
Fontan‐associated liver disease (FALD) is a disorder arising from congestion in the liver. This disease is prominent in patients with hypoplastic left heart syndrome (HLHS). Through perfusion analysis, we find that as FALD progresses, there are increased pressures and decreased flow to certain regions of liver tissue.
Yaqi Li, Justin D. Weigand, Charles Puelz, Mette S. Olufsen, Alyssa Taylor‐Lapole   +4 more
wiley   +1 more source

Commentary: “A new hope” in patients with Fontan circulation: High-risk Fontan operation can be done, but for “perfect Fontan” we still aim [PDF]

, 2021
Yasuhiro Kotani
openalex   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Operação de um ventrículo e meio como uma alternativa para o ventrículo direito hipoplásico [PDF]

, 2010
Objective: Patients with complex congenital heart disease, characterized by right ventricle hypoplasia, had a palliative surgical option with one and a half ventricular repair.Methods: From July 2001 to March 2009, nine patients (mean age 5.2 years ...
Carvalho, Antonio Carlos, Carvalho, Werther Brunow, Maluf, Miguel Angel   +2 more
core   +4 more sources

Obstetric outcome in women with congenital heart disease: A nationwide cohort in Sweden

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 1, Page 7-17, January 2026.
In this large national case–control study in women with congenital heart disease, we showed an increased likelihood of giving birth prematurely, by cesarean section, and having a small‐for‐gestational‐age neonate compared to matched controls. Abstract Introduction Survival and healthcare for patients with congenital heart disease have improved, and the
Frida Wedlund, Ellen Widing, Emma von Wowern, Christina Christensson, Sandra Lindstedt, Peder Sörensson, Aleksandra Trzebiatowska‐Krzynska, Zacharias Mandalenakis, Annika Bay, Bengt Johansson, Joanna Hlebowicz   +10 more
wiley   +1 more source

Iron deficiency and reduced exercise tolerance in adult Fontan patients

Frontiers in Pediatrics
BackgroundThe Fontan procedure allows patients with complex congenital heart defects unsuitable for biventricular repair to reach adulthood; however, it results in a non-physiological circulation characterized by chronically elevated systemic venous ...
Agnieszka Bartczak-Rutkowska, Olga Trojnarska, Sonia Nartowicz, Agata Markiewicz, Maciej Lesiak, Ewa Straburzyńska-Migaj   +5 more
doaj   +1 more source

Dobutamine stress testing in patients with Fontan circulation augmented by biomechanical modeling.

PLoS ONE, 2020
Understanding (patho)physiological phenomena and mechanisms of failure in patients with Fontan circulation-a surgically established circulation for patients born with a functionally single ventricle-remains challenging due to the complex hemodynamics and
Bram Ruijsink, Konrad Zugaj, James Wong, Kuberan Pushparajah, Tarique Hussain, Philippe Moireau, Reza Razavi, Dominique Chapelle, Radomír Chabiniok   +8 more
doaj   +1 more source