Results 11 to 20 of about 647,551 (301)

Health Disparities in Calorie Knowledge and Confidence Among the U.S. Adult Population

Journal of Primary Care & Community Health, 2021
Purpose Obesity prevalence has reached an all-time high in the US, affecting >40% of the population. This study’s objective was to evaluate associations between demographics and self-reported calorie knowledge and self-perceived confidence in calorie ...
Amy M. Lando, Martine S. Ferguson, Linda Verrill, Fanfan Wu, Olivia E. Jones-Dominic, Cecile Punzalan, Beverly J. Wolpert   +6 more
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Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

Particle and Fibre Toxicology, 2017
Background As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was designed to evaluate whether gold (
James L. Weaver, Grainne A. Tobin, Taylor Ingle, Simona Bancos, David Stevens, Rodney Rouse, Kristina E. Howard, David Goodwin, Alan Knapton, Xiaohong Li, Katherine Shea, Sharron Stewart, Lin Xu, Peter L. Goering, Qin Zhang, Paul C. Howard, Jessie Collins, Saeed Khan, Kidon Sung, Katherine M. Tyner   +19 more
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Informing selection of drugs for COVID-19 treatment through adverse events analysis

Scientific Reports, 2021
Coronavirus disease 2019 (COVID-19) is an ongoing pandemic and there is an urgent need for safe and effective drugs for COVID-19 treatment. Since developing a new drug is time consuming, many approved or investigational drugs have been repurposed for ...
Wenjing Guo, Bohu Pan, Sugunadevi Sakkiah, Zuowei Ji, Gokhan Yavas, Yanhui Lu, Takashi E. Komatsu, Madhu Lal-Nag, Weida Tong, Tucker A. Patterson, Huixiao Hong   +10 more
doaj   +1 more source

Atezolizumab potentiates Tcell-mediated cytotoxicity and coordinates with FAK to suppress cell invasion and motility in PD-L1+ triple negative breast cancer cells

OncoImmunology, 2019
Immune check point inhibitors targeting programmed cell death protein-1 (PD-1) and its ligand (PD-L1) have shown clinical success in treatment of human malignancies.
Nishant Mohan, Salman Hosain, Jun Zhao, Yi Shen, Xiao Luo, Jiangsong Jiang, Yukinori Endo, Wen Jin Wu   +7 more
doaj   +1 more source

Modulation of innate immune mechanisms to enhance vaccine induced immunity: Role of co-inhibitory molecules

Frontiers in Immunology, 2016
No licensed human vaccines are currently available against any parasitic disease including leishmaniasis. Several anti-leishmanial vaccine formulations have been tested in various animal models including genetically modified live attenuated parasite ...
Sreenivas eGannavaram, Parna eBhattacharya, Nevien eIsmail, Amit eKaul, Rakesh eSingh, Hira eNakhasi   +5 more
doaj   +1 more source

Development of a custom-designed, pan genomic DNA microarray to characterize strain-level diversity among Cronobacter spp.

Frontiers in Pediatrics, 2015
Cronobacter species cause infections in all age groups; however neonates are at highest risk and remain the most susceptible age group for life-threatening invasive disease. The genus contains seven species: C. sakazakii, C. malonaticus, C. turicensis C.
Ben Davies Tall, Jayanthi eGangiredla, Gopal eGOPINATHRAO, Qiongqiong eYan, Hannah R Chase, B eLee, S eHwang, L eTrach, Eunbi ePark, Y eYoo, TaeJung eChung, Scott eJackson, Isha ePatel, Venugopal eSathyamoorthy, Monica ePava-Ripoll, Michael eKotewicz, Laurenda eCarter, C eIversen, Franco ePagotto, Roger eStephan, A eLehner, Seamus eFanning, Christopher eGrim   +22 more
doaj   +1 more source

Decoding kinase-adverse event associations for small molecule kinase inhibitors

Nature Communications, 2022
Small molecule kinase inhibitors (SMKIs) are being approved at a fast pace under expedited programs for anticancer treatment. Here, the authors employ a machine-learning model to examine the relationships between kinase targets and adverse events in the ...
Xiajing Gong, Meng Hu, Jinzhong Liu, Geoffrey Kim, James Xu, Amy McKee, Todd Palmby, R. Angelo de Claro, Liang Zhao   +8 more
doaj   +1 more source

ALCOHOL AND ALDEHYDE DEHYDROGENASES CONTRIBUTE TO SEX-RELATED DIFFERENCES IN CLEARANCE OF ZOLPIDEM IN RATS

Frontiers in Pharmacology, 2016
Objectives:  The recommended zolpidem starting dose was lowered in females (5mg vs 10mg) since side effects were more frequent and severe than those of males; the mechanism underlying sex differences in pharmacokinetics (PK) is unknown.
Cody J Peer, Jonathan D Strope, Shaunna Beedie, Ariel M Ley, Alesia Holly, Karim Calis, Ronald Farkas, Jagan Parepally, Angela Men, Emmanuel O Fadiran, Pamela Scott, Marjorie Jenkins, William H. Theodore, Tristan M Sissung   +13 more
doaj   +1 more source

Comparison of MiSeq, MinION, and hybrid genome sequencing for analysis of Campylobacter jejuni

Scientific Reports, 2021
The sequencing, assembly, and analysis of bacterial genomes is central to tracking and characterizing foodborne pathogens. The bulk of bacterial genome sequencing at the US Food and Drug Administration is performed using short-read Illumina MiSeq ...
Jason M. Neal-McKinney, Kun C. Liu, Christopher M. Lock, Wen-Hsin Wu, Jinxin Hu   +4 more
doaj   +1 more source

Characterization of Vibrio parahaemolyticus clinical strains from Maryland (2012-2013) and comparisons to a locally and globally diverse V. parahaemolyticus strains by Whole-Genome Sequence Analysis

Frontiers in Microbiology, 2015
Vibrio parahaemolyticus is the leading cause of foodborne illnesses in the US associated with the consumption of raw shellfish. Previous population studies of V.
Julie eHaendiges, Ruth eTimme, Marc William Allard, Robert A Myers, Robert A Myers, Eric Wayne Brown, Narjol eGonzález-Escalona   +6 more
doaj   +1 more source