Results 221 to 230 of about 3,258,233 (341)

Food and Drug Administration, Partner in Drug Development

CA: A Cancer Journal for Clinicians, 2006
openaire   +3 more sources

Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons

Advanced Healthcare Materials, EarlyView.
This study introduces a novel chitosan‐based nanocarrier functionalized with a neurotropic protein for efficient siRNA delivery to neurons. The polyplexes demonstrate enhanced neuronal binding, retrograde transport, and PTEN silencing, promoting axonal outgrowth.
Ana P. Spencer, Adriana Vilaça, Miguel Xavier, Rafael Santos, Ariel Ionescu, María Lázaro, Victoria Leiro, Eran Perlson, Sofia C. Guimarães, Ben M. Maoz, Ana P. Pêgo   +10 more
wiley   +1 more source

Landscape of regulatory quantitative systems pharmacology submissions to the U.S. Food and Drug Administration: An update report. [PDF]

CPT Pharmacometrics Syst Pharmacol
Bai JPF, Liu G, Zhao M, Wang J, Xiong Y, Truong T, Earp JC, Yang Y, Liu J, Zhu H, Burckart GJ.   +10 more
europepmc   +1 more source

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

A food and drug administration request for cooperation

Journal of the American College of Cardiology, 1994
Jeffrey D. Jones, Susan Alpert, Thomas J. Callahan, Mark Barnett   +3 more
openaire   +2 more sources

Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

Advanced Healthcare Materials, EarlyView.
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho, Yunyoung Choi, Yerim Jang, Hyejeong Seong   +3 more
wiley   +1 more source

Tri‐Layered Bioactive Cutaneous Scaffold with Integrated Bioactive Metal Organic Frameworks to Promote Full‐Thickness Infected Diabetic Wound Healing: Multifaceted Therapeutic Strategies

Advanced Healthcare Materials, EarlyView.
The limitations of existing clinical treatments highlight the need for a more comprehensive strategy for addressing infected diabetic wounds. A tri‐layered scaffold is developed to deliver therapeutics loaded in CuBDC and ZIF‐8 MOFs that are tailored to the requirements of deep‐infected diabetic wounds.
Ayse Gunyakti Mujtaba, Ayşe Karakeçili, Berna Topuz, Barış Batur, Okan Onar, Mehmet Eray Elçiğir, Çağdaş Oto, Alireza Hanifehnezhad, Kaan Orhan   +8 more
wiley   +1 more source

Strength of clinical evidence supporting the United States Food and Drug Administration Accelerated Approvals from 2015 to 2022. [PDF]

BMC Med
Zhang X, Peck CC, Wang Y, Szucs TD, Sun W, Bai X, Chen S, Wang F, Wu Y.   +8 more
europepmc   +1 more source

Fabrication of a Lipopolysaccharide‐Targeting Peptide‐Based Colloid for Alleviating Carbapenem‐Resistant Enterobacteriaceae‐Induced Cutaneous Infection

Advanced Healthcare Materials, EarlyView.
In this study, a novel cationic peptide, IW is designed and synthesized, with a tandem‐repeat sequence demonstrating potent activities against a broad spectrum of clinically relevant Carbapenem‐resistant Enterobacteriaceae in both the planktonic and biofilm states. IW is then formulated with P407 to form IW‐P407 colloids.
Ping Zeng, Xinyi Ding, Chenyu Liu, Sheng Chen, Kin‐Fai Chan, Sharon Shui Yee Leung   +5 more
wiley   +1 more source

Hepatotoxicity of statins: a real-world study based on the US Food and Drug Administration Adverse Event Reporting System database. [PDF]

Front Pharmacol
Wang B, Huang S, Li S, Deng Y, Li Z, Wang Y, Shi X, Zhang W, Shi L, Wang X, Tang X.   +10 more
europepmc   +1 more source