Results 21 to 30 of about 3,258,233 (341)
A clustering and graph deep learning-based framework for COVID-19 drug repurposing [PDF]
arXiv, 2023 Drug repurposing (or repositioning) is the process of finding new therapeutic uses for drugs already approved by drug regulatory authorities (e.g., the Food and Drug Administration (FDA) and Therapeutic Goods Administration (TGA)) for other diseases. This involves analyzing the interactions between different biological entities, such as drug targets ...
arxiv
Decoding kinase-adverse event associations for small molecule kinase inhibitors
Nature Communications, 2022 Small molecule kinase inhibitors (SMKIs) are being approved at a fast pace under expedited programs for anticancer treatment. Here, the authors employ a machine-learning model to examine the relationships between kinase targets and adverse events in the ...
Xiajing Gong +8 more
doaj +1 more source
DROID: Dose-ranging Approach to Optimizing Dose in Oncology Drug Development [PDF]
arXiv, 2022 In the era of targeted therapy, there has been increasing concern about the development of oncology drugs based on the "more is better" paradigm, developed decades ago for chemotherapy. Recently, the US Food and Drug Administration (FDA) initiated Project Optimus to reform the dose optimization and dose selection paradigm in oncology drug development ...
arxiv
Frontiers in Pharmacology, 2016 Objectives: The recommended zolpidem starting dose was lowered in females (5mg vs 10mg) since side effects were more frequent and severe than those of males; the mechanism underlying sex differences in pharmacokinetics (PK) is unknown.
Cody J Peer +13 more
doaj +1 more source
Comparison of MiSeq, MinION, and hybrid genome sequencing for analysis of Campylobacter jejuni
Scientific Reports, 2021 The sequencing, assembly, and analysis of bacterial genomes is central to tracking and characterizing foodborne pathogens. The bulk of bacterial genome sequencing at the US Food and Drug Administration is performed using short-read Illumina MiSeq ...
Jason M. Neal-McKinney +4 more
doaj +1 more source
Blood Cancer Journal, 2022 This retrospective observational study evaluated racial disparities among Black and White patients with multiple myeloma (MM). We included patients from a longitudinal de-identified EHR-derived database who had ≥2 visits recorded on or after 1/1/2011 ...
Kathleen Maignan +10 more
doaj +1 more source
Scientific Reports, 2023 Tissue containment systems (TCS) are medical devices that may be used during morcellation procedures during minimally invasive laparoscopic surgery.
Alexander Herman +5 more
doaj +1 more source
BridgeDPI: A Novel Graph Neural Network for Predicting Drug-Protein Interactions [PDF]
arXiv, 2021 Motivation: Exploring drug-protein interactions (DPIs) work as a pivotal step in drug discovery. The fast expansion of available biological data enables computational methods effectively assist in experimental methods. Among them, deep learning methods extract features only from basic characteristics, such as protein sequences, molecule structures ...
arxiv
Frontiers in Microbiology, 2016 The recovery and growth potential of Listeria monocytogenes was evaluated in three flavors of milkshakes (vanilla, strawberry, and chocolate) that were prepared from naturally contaminated ice cream linked to a listeriosis outbreak in the U.S.
Yi eChen +7 more
doaj +1 more source
Communications Biology, 2023 Antimicrobial resistance (AMR) monitoring for public health is relying more on whole genome sequencing to characterize and compare resistant strains. This requires new approaches to describe and track AMR that take full advantage of the detailed data ...
Lucas Harrison +5 more
doaj +1 more source