Results 31 to 40 of about 687,018 (362)

Modulation of innate immune mechanisms to enhance vaccine induced immunity: Role of co-inhibitory molecules

Frontiers in Immunology, 2016
No licensed human vaccines are currently available against any parasitic disease including leishmaniasis. Several anti-leishmanial vaccine formulations have been tested in various animal models including genetically modified live attenuated parasite ...
Sreenivas eGannavaram, Parna eBhattacharya, Nevien eIsmail, Amit eKaul, Rakesh eSingh, Hira eNakhasi   +5 more
doaj   +1 more source

Informing selection of drugs for COVID-19 treatment through adverse events analysis

Scientific Reports, 2021
Coronavirus disease 2019 (COVID-19) is an ongoing pandemic and there is an urgent need for safe and effective drugs for COVID-19 treatment. Since developing a new drug is time consuming, many approved or investigational drugs have been repurposed for ...
Wenjing Guo, Bohu Pan, Sugunadevi Sakkiah, Zuowei Ji, Gokhan Yavas, Yanhui Lu, Takashi E. Komatsu, Madhu Lal-Nag, Weida Tong, Tucker A. Patterson, Huixiao Hong   +10 more
doaj   +1 more source

Assessment of Clinical Trials Supporting US Food and Drug Administration Approval of Novel Therapeutic Agents, 1995-2017

JAMA Network Open, 2020
Key Points Question Have the number and characteristics of pivotal efficacy trials supporting US Food and Drug Administration approval of new drugs and biologics changed during the past 3 decades?
A. Zhang, Jeremy Puthumana, Nicholas Downing, N. Shah, H. Krumholz, J. Ross   +5 more
semanticscholar   +1 more source

Development of a custom-designed, pan genomic DNA microarray to characterize strain-level diversity among Cronobacter spp.

Frontiers in Pediatrics, 2015
Cronobacter species cause infections in all age groups; however neonates are at highest risk and remain the most susceptible age group for life-threatening invasive disease. The genus contains seven species: C. sakazakii, C. malonaticus, C. turicensis C.
Ben Davies Tall, Jayanthi eGangiredla, Gopal eGOPINATHRAO, Qiongqiong eYan, Hannah R Chase, B eLee, S eHwang, L eTrach, Eunbi ePark, Y eYoo, TaeJung eChung, Scott eJackson, Isha ePatel, Venugopal eSathyamoorthy, Monica ePava-Ripoll, Michael eKotewicz, Laurenda eCarter, C eIversen, Franco ePagotto, Roger eStephan, A eLehner, Seamus eFanning, Christopher eGrim   +22 more
doaj   +1 more source

Global COVID‐19 pandemic and reporting behavior ‐ An analysis of the Food and Drug Administration adverse events reporting system

Pharmacoepidemiology and Drug Safety, 2021
To describe the characteristics of adverse event reporting in the United States (US) Food and Drug Administration Adverse Event Reporting System (FAERS) before and after the outbreak of the COVID‐19 pandemic.
M. Dörks, K. Jobski, F. Hoffmann, A. Douros   +3 more
semanticscholar   +1 more source

Atezolizumab potentiates Tcell-mediated cytotoxicity and coordinates with FAK to suppress cell invasion and motility in PD-L1+ triple negative breast cancer cells

OncoImmunology, 2019
Immune check point inhibitors targeting programmed cell death protein-1 (PD-1) and its ligand (PD-L1) have shown clinical success in treatment of human malignancies.
Nishant Mohan, Salman Hosain, Jun Zhao, Yi Shen, Xiao Luo, Jiangsong Jiang, Yukinori Endo, Wen Jin Wu   +7 more
doaj   +1 more source

Decoding kinase-adverse event associations for small molecule kinase inhibitors

Nature Communications, 2022
Small molecule kinase inhibitors (SMKIs) are being approved at a fast pace under expedited programs for anticancer treatment. Here, the authors employ a machine-learning model to examine the relationships between kinase targets and adverse events in the ...
Xiajing Gong, Meng Hu, Jinzhong Liu, Geoffrey Kim, James Xu, Amy McKee, Todd Palmby, R. Angelo de Claro, Liang Zhao   +8 more
doaj   +1 more source

Comparison of MiSeq, MinION, and hybrid genome sequencing for analysis of Campylobacter jejuni

Scientific Reports, 2021
The sequencing, assembly, and analysis of bacterial genomes is central to tracking and characterizing foodborne pathogens. The bulk of bacterial genome sequencing at the US Food and Drug Administration is performed using short-read Illumina MiSeq ...
Jason M. Neal-McKinney, Kun C. Liu, Christopher M. Lock, Wen-Hsin Wu, Jinxin Hu   +4 more
doaj   +1 more source

Mechanisms of resistance to BRAF and MEK inhibitors and clinical update of US Food and Drug Administration-approved targeted therapy in advanced melanoma

OncoTargets and Therapy, 2018
Approximately 50% of melanomas harbor an activating BRAF mutation. Combined BRAF and MEK inhibitors such as dabrafenib and trametinib, vemurafenib and cobimetinib, and encorafenib and binimetinib are US Food and Drug Administration (FDA)-approved to ...
Sunil Kakadia, N. Yarlagadda, Ramez Awad, M. Kundranda, J. Niu, B. Naraev, L. Mina, T. Dragovich, M. Gimbel, Fade Mahmoud   +9 more
semanticscholar   +1 more source

ALCOHOL AND ALDEHYDE DEHYDROGENASES CONTRIBUTE TO SEX-RELATED DIFFERENCES IN CLEARANCE OF ZOLPIDEM IN RATS

Frontiers in Pharmacology, 2016
Objectives:  The recommended zolpidem starting dose was lowered in females (5mg vs 10mg) since side effects were more frequent and severe than those of males; the mechanism underlying sex differences in pharmacokinetics (PK) is unknown.
Cody J Peer, Jonathan D Strope, Shaunna Beedie, Ariel M Ley, Alesia Holly, Karim Calis, Ronald Farkas, Jagan Parepally, Angela Men, Emmanuel O Fadiran, Pamela Scott, Marjorie Jenkins, William H. Theodore, Tristan M Sissung   +13 more
doaj   +1 more source