Results 31 to 40 of about 651,817 (302)

Investigation of thrombin concentration at the time of clot formation in simultaneous thrombin and fibrin generation assays

Scientific Reports
Thrombin generation (TG) and fibrin clot formation represent the central process of blood coagulation. Up to 95% of thrombin is considered to be generated after the clot is formed. However, this was not investigated in depth.
Ivan D. Tarandovskiy, Stepan S. Surov, Leonid A. Parunov, Yideng Liang, Wojciech Jankowski, Zuben E. Sauna, Mikhail V. Ovanesov   +6 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA

BMC Bioinformatics, 2019
Background Adverse Drug Reactions (ADRs) are of great public health concern. FDA-approved drug labeling summarizes ADRs of a drug product mainly in three sections, i.e., Boxed Warning (BW), Warnings and Precautions (WP), and Adverse Reactions (AR), where
Leihong Wu, Taylor Ingle, Zhichao Liu, Anna Zhao-Wong, Stephen Harris, Shraddha Thakkar, Guangxu Zhou, Junshuang Yang, Joshua Xu, Darshan Mehta, Weigong Ge, Weida Tong, Hong Fang   +12 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Enhancing the incorporation of the patient’s voice in drug development and evaluation

Research Involvement and Engagement, 2018
Plain English summary People living with a condition are uniquely positioned to inform the understanding of the therapeutic context for drug development and evaluation. In 2012, the U.S.
Meghana Chalasani, Pujita Vaidya, Theresa Mullin   +2 more
doaj   +1 more source

Predicting potential adverse events using safety data from marketed drugs

BMC Bioinformatics, 2020
Background While clinical trials are considered the gold standard for detecting adverse events, often these trials are not sufficiently powered to detect difficult to observe adverse events.
Chathuri Daluwatte, Peter Schotland, David G. Strauss, Keith K. Burkhart, Rebecca Racz   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Identification of Bradycardia Following Remdesivir Administration Through the US Food and Drug Administration American College of Medical Toxicology COVID-19 Toxic Pharmacovigilance Project [PDF]

, 2023
Jason M. Devgun, Rongmei Zhang, Jeffrey Brent, Paul M. Wax, Keith Burkhart, Alison Meyn, Sharan Campleman, Stephanie Abston, Kim Aldy, Maryann Amirshahi, Katherine Boyle, Jennie Buchanan, Jennifer Carey, Kennon Heard, Robert G. Hendrickson, Ziad Kazzi, Eric J. Lavonas, Michael P. Levine, Travis D. Olives, Anthony F. Pizon, Jonathan Schimmel, Kapil Sharma, Meghan B. Spyres, Timothy J. Wiegand   +23 more
openalex   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Assessment of plasmids for relating the 2020 Salmonella enterica serovar Newport onion outbreak to farms implicated by the outbreak investigation

BMC Genomics, 2023
Background The Salmonella enterica serovar Newport red onion outbreak of 2020 was the largest foodborne outbreak of Salmonella in over a decade. The epidemiological investigation suggested two farms as the likely source of contamination.
Seth Commichaux, Hugh Rand, Kiran Javkar, Erin K. Molloy, James B. Pettengill, Arthur Pightling, Maria Hoffmann, Mihai Pop, Victor Jayeola, Steven Foley, Yan Luo   +10 more
doaj   +1 more source