Results 31 to 40 of about 731,751 (310)

Atezolizumab potentiates Tcell-mediated cytotoxicity and coordinates with FAK to suppress cell invasion and motility in PD-L1+ triple negative breast cancer cells

OncoImmunology, 2019
Immune check point inhibitors targeting programmed cell death protein-1 (PD-1) and its ligand (PD-L1) have shown clinical success in treatment of human malignancies.
Nishant Mohan, Salman Hosain, Jun Zhao, Yi Shen, Xiao Luo, Jiangsong Jiang, Yukinori Endo, Wen Jin Wu   +7 more
doaj   +1 more source

Modulation of innate immune mechanisms to enhance vaccine induced immunity: Role of co-inhibitory molecules

Frontiers in Immunology, 2016
No licensed human vaccines are currently available against any parasitic disease including leishmaniasis. Several anti-leishmanial vaccine formulations have been tested in various animal models including genetically modified live attenuated parasite ...
Sreenivas eGannavaram, Parna eBhattacharya, Nevien eIsmail, Amit eKaul, Rakesh eSingh, Hira eNakhasi   +5 more
doaj   +1 more source

Development of a custom-designed, pan genomic DNA microarray to characterize strain-level diversity among Cronobacter spp.

Frontiers in Pediatrics, 2015
Cronobacter species cause infections in all age groups; however neonates are at highest risk and remain the most susceptible age group for life-threatening invasive disease. The genus contains seven species: C. sakazakii, C. malonaticus, C. turicensis C.
Ben Davies Tall, Jayanthi eGangiredla, Gopal eGOPINATHRAO, Qiongqiong eYan, Hannah R Chase, B eLee, S eHwang, L eTrach, Eunbi ePark, Y eYoo, TaeJung eChung, Scott eJackson, Isha ePatel, Venugopal eSathyamoorthy, Monica ePava-Ripoll, Michael eKotewicz, Laurenda eCarter, C eIversen, Franco ePagotto, Roger eStephan, A eLehner, Seamus eFanning, Christopher eGrim   +22 more
doaj   +1 more source

Decoding kinase-adverse event associations for small molecule kinase inhibitors

Nature Communications, 2022
Small molecule kinase inhibitors (SMKIs) are being approved at a fast pace under expedited programs for anticancer treatment. Here, the authors employ a machine-learning model to examine the relationships between kinase targets and adverse events in the ...
Xiajing Gong, Meng Hu, Jinzhong Liu, Geoffrey Kim, James Xu, Amy McKee, Todd Palmby, R. Angelo de Claro, Liang Zhao   +8 more
doaj   +1 more source

Mechanisms of resistance to BRAF and MEK inhibitors and clinical update of US Food and Drug Administration-approved targeted therapy in advanced melanoma

OncoTargets and Therapy, 2018
Approximately 50% of melanomas harbor an activating BRAF mutation. Combined BRAF and MEK inhibitors such as dabrafenib and trametinib, vemurafenib and cobimetinib, and encorafenib and binimetinib are US Food and Drug Administration (FDA)-approved to ...
Sunil Kakadia, N. Yarlagadda, Ramez Awad, M. Kundranda, J. Niu, B. Naraev, L. Mina, T. Dragovich, M. Gimbel, Fade Mahmoud   +9 more
semanticscholar   +1 more source

ALCOHOL AND ALDEHYDE DEHYDROGENASES CONTRIBUTE TO SEX-RELATED DIFFERENCES IN CLEARANCE OF ZOLPIDEM IN RATS

Frontiers in Pharmacology, 2016
Objectives:  The recommended zolpidem starting dose was lowered in females (5mg vs 10mg) since side effects were more frequent and severe than those of males; the mechanism underlying sex differences in pharmacokinetics (PK) is unknown.
Cody J Peer, Jonathan D Strope, Shaunna Beedie, Ariel M Ley, Alesia Holly, Karim Calis, Ronald Farkas, Jagan Parepally, Angela Men, Emmanuel O Fadiran, Pamela Scott, Marjorie Jenkins, William H. Theodore, Tristan M Sissung   +13 more
doaj   +1 more source

Comparison of MiSeq, MinION, and hybrid genome sequencing for analysis of Campylobacter jejuni

Scientific Reports, 2021
The sequencing, assembly, and analysis of bacterial genomes is central to tracking and characterizing foodborne pathogens. The bulk of bacterial genome sequencing at the US Food and Drug Administration is performed using short-read Illumina MiSeq ...
Jason M. Neal-McKinney, Kun C. Liu, Christopher M. Lock, Wen-Hsin Wu, Jinxin Hu   +4 more
doaj   +1 more source

Characterization of Vibrio parahaemolyticus clinical strains from Maryland (2012-2013) and comparisons to a locally and globally diverse V. parahaemolyticus strains by Whole-Genome Sequence Analysis

Frontiers in Microbiology, 2015
Vibrio parahaemolyticus is the leading cause of foodborne illnesses in the US associated with the consumption of raw shellfish. Previous population studies of V.
Julie eHaendiges, Ruth eTimme, Marc William Allard, Robert A Myers, Robert A Myers, Eric Wayne Brown, Narjol eGonzález-Escalona   +6 more
doaj   +1 more source

Exploring racial disparities in treatment patterns and outcomes for patients with multiple myeloma using real world data

Blood Cancer Journal, 2022
This retrospective observational study evaluated racial disparities among Black and White patients with multiple myeloma (MM). We included patients from a longitudinal de-identified EHR-derived database who had ≥2 visits recorded on or after 1/1/2011 ...
Kathleen Maignan, Lola A. Fashoyin-Aje, Aracelis Z. Torres, Laura L. Fernandes, Thomas Gwise, Shrujal B. Baxi, James P. Roose, Donna R. Rivera, Yuan Li Shen, Paul G. Kluetz, Nicole J. Gormley   +10 more
doaj   +1 more source

Development of Drug-Device Combination Products and Generic Substitution in the United States

INNOVATIONS in Pharmacy
Generic drug products approved and marketed in the United States include a variety of drug classes and dosage forms along with drug-device combination products (DDCPs).
YoonJung Lee, Ila Srivastava, Katharine B. Feibus, Elizabeth R. Bielski, Lolita Sterrett, Danielle Harris, Markham C. Luke   +6 more
doaj   +1 more source