Results 41 to 50 of about 731,751 (310)

Mechanical and leakage integrity testing considerations for evaluating the performance of tissue containment systems

Scientific Reports, 2023
Tissue containment systems (TCS) are medical devices that may be used during morcellation procedures during minimally invasive laparoscopic surgery.
Alexander Herman, Nandini Duraiswamy, Poulomi Nandy, Veronica Price, George Gibeily, Prasanna Hariharan   +5 more
doaj   +1 more source

Estimated Costs of Pivotal Trials for Novel Therapeutic Agents Approved by the US Food and Drug Administration, 2015-2016

JAMA Internal Medicine, 2018
Importance A critical question in health care is the extent of scientific evidence that should be required to establish that a new therapeutic agent has benefits that outweigh its risks.
Thomas J. Moore, Hanzhe Zhang, G. Anderson, G. Caleb Alexander   +3 more
semanticscholar   +1 more source

Peptide Nucleic Acid Probe Detection of Mutations in Mycobacterium tuberculosis Genes Associated with Drug Resistance

BioTechniques, 2002
The emergence of drug-resistant strains of Mycobacterium tuberculosis is a serious public health problem. Many of the specific gene mutations that cause drug resistance in M. tuberculosis are point mutations. We are developing a PCR-peptide nucleic acid (
L.E. Bockstahler, Z. Li, N.Y. Nguyen, K.A. Van Houten, M.J. Brennan, J.J. Langone, S.L. Morris   +6 more
doaj   +1 more source

Lociq provides a loci-seeking approach for enhanced plasmid subtyping and structural characterization

Communications Biology, 2023
Antimicrobial resistance (AMR) monitoring for public health is relying more on whole genome sequencing to characterize and compare resistant strains. This requires new approaches to describe and track AMR that take full advantage of the detailed data ...
Lucas Harrison, Shaohua Zhao, Cong Li, Patrick F. McDermott, Gregory H. Tyson, Errol Strain   +5 more
doaj   +1 more source

Complementing the US Food and Drug Administration Adverse Event Reporting System With Adverse Drug Reaction Reporting From Social Media: Comparative Analysis

JMIR Public Health and Surveillance, 2020
Background Adverse drug reactions (ADRs) can occur any time someone uses a medication. ADRs are systematically tracked and cataloged, with varying degrees of success, in order to better understand their etiology and develop methods of prevention.
Zeyun Zhou, K. Hultgren
semanticscholar   +1 more source

Recovery and growth potential of Listeria monocytogenes in temperature abused milkshakes prepared from naturally contaminated ice cream linked to a listeriosis outbreak

Frontiers in Microbiology, 2016
The recovery and growth potential of Listeria monocytogenes was evaluated in three flavors of milkshakes (vanilla, strawberry, and chocolate) that were prepared from naturally contaminated ice cream linked to a listeriosis outbreak in the U.S.
Yi eChen, Emma eAllard, Anna eWooten, Minji eHur, Ishani eSheth, Anna eLassri, Thomas S Hammack, Dumitru eMacarisin   +7 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Review of patient-reported outcomes in multiple myeloma registrational trials: highlighting areas for improvement

Blood Cancer Journal, 2021
Over the past 13 years, there have been advances in characterizing the patient experience in oncology trials, primarily using patient-reported outcomes (PROs). This review aims to provide details on the PRO measures and analyses used in multiple myeloma (
Laura L. Fernandes, Jiaxi Zhou, Bindu Kanapuru, Erica Horodniceanu, Thomas Gwise, Paul G. Kluetz, Vishal Bhatnagar   +6 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Unapproved Pharmaceutical Ingredients Included in Dietary Supplements Associated With US Food and Drug Administration Warnings

JAMA Network Open, 2018
Key Points Question What are the trends across adulterated dietary supplements associated with a warning released by the US Food and Drug Administration from 2007 through 2016?
Jenna N. Tucker, Tessa Fischer, Laurence Upjohn, D. Mazzera, Madhur Kumar   +4 more
semanticscholar   +1 more source