Results 141 to 150 of about 4,823,473 (313)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Surveillance of West Nile virus infections in humans and animals in Europe, monthly report – data submitted up to 5 November 2025

open access: yesEFSA Journal
Epidemiological summary In 2025, and as of 5 November 2025, 14 countries in Europe reported 1 096 locally acquired1 human cases of WNV infection with known place of infection. The earliest and latest date of onset were on 19 May 2025 and 27 October 2025,
European Centre for Disease Prevention and Control (ECDC)   +1 more
doaj   +1 more source

Regionalised Food Control

open access: yes, 2003
Download for free Dette er sluttrapporten fra en evaluering av SNTs regionaliseringsprosjekt. I prosjektet er det prøvd ut fire ulike regionmodeller. Rapporten belyser hvilke resultater en har oppnådd i forhold til målene med prosjektet. Analysene indikerer at opprettelse av regionkontor har bidratt til positive resultater i forhold til mål om bedre ...
Leif Arne Heløe   +2 more
openaire  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

The European Union One Health 2023 Zoonoses report

open access: yesEFSA Journal
This report by the European Food Safety Authority and the European Centre for Disease Prevention and Control presents the results of zoonoses monitoring and surveillance activities carried out in 2023 in 27 Member States (MSs), the United Kingdom ...
European Food Safety Authority (EFSA)   +1 more
doaj   +1 more source

Proceedings of the National Conference on Water, Food Security and Climate Change in Sri Lanka, BMICH, Colombo, Sri Lanka, 9-11 June 2009. Vol. 1. Irrigation for food security [PDF]

open access: yes
Food security / Climate change / River basins / Water shortage / Irrigated farming / Water quality / Tanks / Aquatic plants / Rice / Food insecurity / Water resource management / Zero tillage / Weed control / Agroforestry / Canals / Surface runoff ...
Godaliyadda, G. G. A.   +2 more
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

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