Results 281 to 290 of about 3,381,292 (316)
Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy
Advanced Functional Materials, EarlyView.Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia +9 morewiley +1 more sourceGovernance and resilience as entry points for transforming food systems in the countdown to 2030. [PDF]
Nat FoodSchneider KR, Remans R, Bekele TH, Aytekin D, Conforti P, Dasgupta S, DeClerck F, Dewi D, Fabi C, Gephart JA, Masuda YJ, McLaren R, Saisana M, Aburto N, Ambikapathi R, Arellano Rodriguez M, Barquera S, Battersby J, Beal T, Béné C, Cafiero C, Campeau C, Caron P, Cattaneo A, Candel J, Covic N, Del Pino Alvarez I, Dominguez Barreto AP, Elouafi I, Frazier TJ, Fremier A, Foley P, Golden CD, Gonzalez Fischer C, Guarin A, Hendriks S, Herforth A, Honorati M, Huang J, Getaneh Y, Kennedy G, Laar A, Lal R, Lidder P, Feye GL, Loken B, Malapit H, Marshall Q, Mulatu KA, Munguia A, Nordhagen S, Resnick D, Suhardiman D, Sumaila UR, Sun B, Mengesha BT, Torero Cullen M, Tubiello FN, Dooren CV, Valero Morales I, Vivero-Pol JL, Webb P, Wiebe K, Haddad L, Herrero M, Rosero Moncayo J, Fanzo J. +66 moreeuropepmc +1 more sourceCholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1
Advanced Functional Materials, EarlyView.This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged +19 morewiley +1 more sourceTransducer Materials Mediated Deep Brain Stimulation in Neurological Disorders
Advanced Functional Materials, EarlyView.This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao +5 morewiley +1 more sourceAuthor Correction: Governance and resilience as entry points for transforming food systems in the countdown to 2030. [PDF]
Nat FoodSchneider KR, Remans R, Bekele TH, Aytekin D, Conforti P, Dasgupta S, DeClerck F, Dewi D, Fabi C, Gephart JA, Masuda YJ, McLaren R, Saisana M, Aburto N, Ambikapathi R, Arellano Rodriguez M, Barquera S, Battersby J, Beal T, Béné C, Cafiero C, Campeau C, Caron P, Cattaneo A, Candel J, Covic N, Del Pino Alvarez I, Dominguez Barreto AP, Elouafi I, Frazier TJ, Fremier A, Foley P, Golden CD, Gonzalez Fischer C, Guarin A, Hendriks S, Herforth A, Honorati M, Huang J, Getaneh Y, Kennedy G, Laar A, Lal R, Lidder P, Feye GL, Loken B, Malapit H, Marshall Q, Mulatu KA, Munguia A, Nordhagen S, Resnick D, Suhardiman D, Sumaila UR, Sun B, Mengesha BT, Torero Cullen M, Tubiello FN, Dooren CV, Valero Morales I, Vivero-Pol JL, Webb P, Wiebe K, Haddad L, Herrero M, Rosero Moncayo J, Fanzo J. +66 moreeuropepmc +1 more sourceAnionic Citrate‐Based 3D‐Printed Scaffolds for Tunable and Sustained Orthobiologic Delivery to Enhance Tissue Regeneration
Advanced Functional Materials, EarlyView.A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...Se‐Hwan Lee, Ruqiang Lu, Andrew House, Zizhao Li, Lindsey Hammond Burton, Katie Josephine Sikes, Lynn Marie Pezzanite, Drew William Koch, Kevin Michael Labus, Ben Gadomski, Jeremiah Easley, Richard Tuan Tran, Su Chin Heo +12 morewiley +1 more source