Results 61 to 70 of about 282,050 (325)

Foot-and-mouth disease: past, present and future [PDF]

, 2013
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals including cattle, pigs, sheep and many wildlife species. It can cause enormous economic losses when incursions occur into countries which are normally disease free.
Belsham, Graham, Jamal, Syed Muhammad
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Analysis of Amino Acid Mutations of the Foot-and-Mouth Disease Virus Serotype O Using both Heparan Sulfate and JMJD6 Receptors

Viruses, 2020
Foot-and-mouth disease (FMD) is an economically devastating animal disease. Adapting the field virus to cells is critical to the vaccine production of FMD viruses (FMDV), and heparan sulfate (HS) and Jumonji C-domain-containing protein 6 (JMJD6) are ...
Gyeongmin Lee, Ji-Hyeon Hwang, Aro Kim, Jong-Hyeon Park, Min Ja Lee, Byounghan Kim, Su-Mi Kim   +6 more
doaj   +1 more source

Bovine Genome-wide Association Study for Genetic Elements to Resist the Infection of Foot-and-mouth Disease in the Field [PDF]

Asian-Australasian Journal of Animal Sciences, 2015
Foot-and-mouth disease (FMD) is a highly contagious disease affecting cloven-hoofed animals and causes severe economic loss and devastating effect on international trade of animal or animal products.
Bo-Young Lee, Kwang-Nyeong Lee, Taeheon Lee, Jong-Hyeon Park, Su-Mi Kim, Hyang-Sim Lee, Dong-Su Chung, Hang-Sub Shim, Hak-Kyo Lee, Heebal Kim   +9 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Evaluation of humoral and cellular immune responses induced by a cocktail of recombinant African swine fever virus antigens fused with OprI in domestic pigs

Virology Journal, 2023
Background African swine fever (ASF) is a highly fatal disease in domestic pigs caused by ASF virus (ASFV), for which there is currently no commercial vaccine available.
Guanglei Zhang, Wei Liu, Sicheng Yang, Shuai Song, Yunyun Ma, Guangqing Zhou, Xiaxia Liang, Chun Miao, Junhui Li, Yanhong Liu, Junjun Shao, Huiyun Chang   +11 more
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Correction to: Intercellular transmission of Seneca Valley virus mediated by exosomes

Veterinary Research, 2020
An amendment to this paper has been published and can be accessed via the original article.
Guowei Xu, Shouxing Xu, Xijuan Shi, Chaochao Shen, Junhong Hao, Minhao Yan, Dajun Zhang, Zixiang Zhu, Keshan Zhang, Haixue Zheng, Xiangtao Liu   +10 more
doaj   +1 more source

In vitro and in vivo analyses of co-infections with peste des petits ruminants and capripox vaccine strains

Virology Journal, 2021
Background Peste des petits ruminants (PPR) and goat pox (GTP) are two devastating animal epidemic diseases that affect small ruminants. Vaccination is one of the most important measures to prevent and control these two severe infectious diseases ...
Dajun Zhang, Bo Yang, Ting Zhang, Xijuan Shi, Chaochao Shen, Haixue Zheng, Xiangtao Liu, Keshan Zhang   +7 more
doaj   +1 more source