Results 91 to 100 of about 2,090,287 (327)

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

open access: yesFEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo   +11 more
wiley   +1 more source

Acute compartment syndrome after a lapidus-akin procedure: A case report

open access: yesFoot & Ankle Surgery: Techniques, Reports & Cases, 2022
Acute compartment syndrome is a limb threatening condition typically associated with traumatic injury; however, it can be associated with surgical procedures such as abdominal and pelvic surgeries as well as hip and knee arthroplasty. In this case report,
Rimvydas P. Statkus, DPM FACFAS   +3 more
doaj  

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

open access: yesFEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto   +5 more
wiley   +1 more source

Mycetoma foot

open access: yesJournal of Family and Community Medicine, 2013
Mycetoma is an uncommon chronic granulomatous infective disease of the skin, dermis and subcutaneous tissues predominantly seen in tropical countries. A patient presented to our hospital with the swelling of the left foot with a healed sinus and a painful nodule.
Somnath Gooptu   +3 more
openaire   +4 more sources

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao   +34 more
wiley   +1 more source

Diagnostic Challenge: The Case of a 70‐Year‐Old Man Who Presents With Progressive Vision Loss and Headaches

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 70‐year‐old presents with 6 weeks of progressive bilateral vision loss and headaches. He was also recently treated for presumed sciatica. His exam on admission is notable for poor visual acuity (no light perception), optic nerve atrophy bilaterally with swelling and disc hemorrhage on the left eye and left foot drop.
Malya Sahu, Rohini Samudralwar
wiley   +1 more source

Electric Charge Quantization

open access: yes, 1992
Experimentally it has been known for a long time that the electric charges of the observed particles appear to be quantized. An approach to understanding electric charge quantization that can be used for gauge theories with explicit $U(1)$ factors ...
Babu K S   +25 more
core   +1 more source

Factors for Rituximab Refractoriness in AQP4‐IgG+ NMOSD: A Cohort Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune condition of the central nervous system (CNS), often associated with aquaporin‐4 antibodies (AQP4‐IgG). Rituximab, a CD20+ B‐cell depleting monoclonal antibody, is widely used as first‐line therapy.
Mariano Marrodan   +8 more
wiley   +1 more source

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