Results 91 to 100 of about 2,194,974 (347)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The efficacy of autologous matrix-induced chondrogenesis (AMIC) for osteochondral lesions of the talus in the mid-long term: a systematic review and meta-analysis

Journal of Orthopaedic Surgery and Research
Purpose The objective of this study was to provide a comprehensive review of the existing literature regarding the treatment of osteochondral lesions of the talus (OLT) using autologous matrix-induced chondrogenesis (AMIC), while also discussing the mid ...
Ning Jiang, Haomin Li, Jia Wang, Lin Shen, Xiantie Zeng   +4 more
doaj   +1 more source

\nu_\mu<->\nu_\tau vs \nu_\mu<->\nu_s solutions for the atmospheric neutrino problem

, 1998
The $\nu_\mu \leftrightarrow\nu_\tau$ and $\nu_\mu \leftrightarrow\nu_s$ solutions to the atmospheric neutrino problem are compared with Superkamiokande data.
Akhmedov, Barbieri, Barbieri, Bowes, Enqvist, Enqvist, Foot, Foot, Foot, Foot, Foot, Foot, Fukuda, Fukuda, Giunti, Hirata, Kainulainen, Kajita, Kajita, Kobayashi, Maki, Mikheyev, Mikheyev, Mikheyev, Notzold, Osamu Yasuda, Shi, Vissani, Wolfenstein   +28 more
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Effectiveness of intramedullary nails in Tibiotalocalcaneal arthrodesis for Charcot neuroarthropathy: a systematic review and meta-analysis

Journal of Orthopaedic Surgery and Research
Objective To systematically evaluate the efficacy and safety of intramedullary nails (IMNs) in tibial-talocalcaneal arthrodesis (TTCA) for treating Charcot neuroarthropathy (CN). Methods A comprehensive search for relevant literature was conducted in the
Hao Zhang, Ning Jiang, Jun-Fei Zhao, Xian-Tie Zeng   +3 more
doaj   +1 more source

Mirror dark matter explanation of the DAMA, CoGeNT and CRESST-II data [PDF]

, 2012
Dark matter might reside in a hidden sector which contains an unbroken $U(1)'$ gauge interaction kinetically mixed with standard $U(1)_Y$. Mirror dark matter provides a well motivated example of such a theory.
Foot, R.
core  

Electric charge quantization without anomalies?

, 1994
In gauge theories like the standard model, the electric charges of the fermions can be heavily constrained from the classical structure of the theory and from the cancellation of anomalies.
H. F. Dylla, J. Baumann, J. Bernstein, J. S. Bell, K. S. Babu, L. Alvarez Gaume, M. Marinelli, R. Delbourgo, R. Foot, R. Foot, R. Foot, R. Foot, R. N. Mohapatra, S. Adler, S. Davidson, T. Eguchi   +15 more
core   +2 more sources

Topical and Capsular RM Diabetes Wound Cure for Treatment of Diabetic Foot Ulcer [PDF]

, 2022
George Uchenna Eleje, George Uchenna Eleje, Chidiebele Malachy Ezeude, Celestine Ogonna Oguejiofor, Charlotte Blanche Oguejiofor, Iffiyeosuo Dennis Ake, Patrick Maxwell Uche, Ifeoma Clara Ajuba, Chinyelu Uchenna Ufoaroh, Ekene Agatha Emeka, Arinze Anthony Onwuegbuna, Chisom God’swill Chigbo, Kindness Chidi Irikannu, Ekeuda Uchenna Nwankwo   +13 more
openalex   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source