Results 31 to 40 of about 434,683 (269)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Complete coding region sequence analyses and antigenic characterization of emerging lineage G-IX of foot- and-mouth disease virus serotype Asia1

Veterinary Quarterly
Foot-and-mouth disease Virus (FMDV) serotype Asia1 is prevalent in the Indian subcontinent, with only G-III and G-VIII reported in India until 2020. However, in 2019, a novel genetic group within serotype Asia1, designated as G-IX, emerged in Bangladesh,
Manoranjan Rout, Shyam Singh Dahiya, Saravanan Subramaniam, Ramakant Acharya, Reshama Samanta, Jitendra Kumar Biswal, Jajati Keshari Mohapatra, Rabindra Prasad Singh   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Skin Advanced Glycation End Products among Subjects with Type 2 Diabetes Mellitus with or without Distal Sensorimotor Polyneuropathy

Journal of Diabetes Research, 2021
Aim of the Study. To examine the correlation between skin AGEs and parameters of distal sensorimotor polyneuropathy (DSPN) in type 2 diabetes mellitus (T2DM). Materials and Methods.
Stella Papachristou, Kalliopi Pafili, Grigorios Trypsianis, Dimitrios Papazoglou, Konstantinos Vadikolias, Nikolaos Papanas   +5 more
doaj   +1 more source

Staged management of a large ischemic heel ulcer in a diabetes patient: a case report

Frontiers in Endocrinology, 2023
Heel ulcer is one of the severe complications of patients with diabetes mellitus, which poses a high risk for foot infection and amputation, especially in patients with peripheral arterial disease and neuropathy.
Yuedong Chen, Hui Yang, Wei Wang, Yinchen Chen, Dong Jiang, Yihui Li, Liyi Li, Wengbo Yang, Aiping Wang   +8 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The Online Emergence of Pushback on Social Media in the United States: A Historical Discourse Analysis

International Journal of Communication, 2014
Little is known about resistance to digital media in general and to social media in particular—especially beyond the realm of individuals enacting their media preferences.
Kirsten Foot
doaj  

Estimation of seroconversion and vaccination impact against FMD in India during 2006–2022 using survey sampling and Bayesian approaches

Scientific Reports
In India, the eligible bovine population has been subjected to mandatory biannual Foot-and-mouth Disease (FMD) vaccination since 2004–05 and year-round serosurveillance to control FMD.
Samarendra Das, Bighneswar Barik, Saravanan Subramaniam, Jajati Keshari Mohapatra, Rabindra Prasad Singh   +4 more
doaj   +1 more source

Acute compartment syndrome after a lapidus-akin procedure: A case report

Foot & Ankle Surgery: Techniques, Reports & Cases, 2022
Acute compartment syndrome is a limb threatening condition typically associated with traumatic injury; however, it can be associated with surgical procedures such as abdominal and pelvic surgeries as well as hip and knee arthroplasty. In this case report,
Rimvydas P. Statkus, DPM FACFAS, Joseph D Rundell, DPM, Deepali Darji, DPM, Patrick McEneaney, DPM FACFAS   +3 more
doaj   +1 more source