Results 81 to 90 of about 2,205,957 (345)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Chronic syndesmosis MRI findings compared to arthroscopy findings

Foot & Ankle Surgery: Techniques, Reports & Cases
Injuries to the distal tibiofibular syndesmosis are less common than lateral ankle sprains but are frequently associated with persistent pain and functional impairment when not accurately diagnosed.
Brady Webb, DPM, AACFAS, Marcell Brikho, DPM AACFAS, Avery Mason, DPM, AACFAS, Akhila Issac, DPM, AACFAS, David Waters, DPM, FACFAS   +4 more
doaj   +1 more source

Mirror dark matter explanation of the DAMA, CoGeNT and CRESST-II data [PDF]

, 2012
Dark matter might reside in a hidden sector which contains an unbroken $U(1)'$ gauge interaction kinetically mixed with standard $U(1)_Y$. Mirror dark matter provides a well motivated example of such a theory.
Foot, R.
core  

Effects for atmospheric neutrino experiments from electron neutrino oscillations

, 1997
The minimal interpretation of the atmospheric neutrino data suggests that the muon neutrino oscillates into another species with a mixing angle close to the maximal $\pi/4$.
Acker, Acker, Aglietta, Allison, Athanassopoulos, Athanassopoulos, Barger, Barger, Barger, Calabresu, Casper, Casper, Conforto, Daum, Foot, Foot, Foot, Foot, Foot, Fukuda, Fukuda, Fukuda, Gelmini, Giunti, Giunti, Glashow, Gribov, Harrison, Hidaka, J. Bunn, Kawasaki, Kobayashi, Krastev, Kuo, Learned, Mikheyev, Notzold, R. Foot, R.R. Volkas, Torrente-Lujan, Wolfenstein, Wolfenstein   +41 more
core   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Foot and Ankle Somatosensory Deficits Affect Balance and Motor Function in Children With Cerebral Palsy [PDF]

, 2020
Anastasia Zarkou, Samuel C. K. Lee, Laura A. Prosser, John J. Jeka   +3 more
openalex   +1 more source

Experimental implications of mirror matter-type dark matter

, 2003
Mirror matter-type dark matter is one dark matter candidate which is particularly well motivated from high energy physics. The theoretical motivation and experimental evidence are pedagogically reviewed, with emphasis on the implications of recent ...
Berezhiani Z., Bernabei R., Collie M., Foot R., Foot R., Foot R., Glashow S. L., Gninenko S. N., Holdom B., Lee T. D., ROBERT FOOT, Yu. Ignatiev A.   +11 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Resolution of the small scale structure issues with dissipative dark matter from multiple Standard Model sectors

, 2018
Dissipative dark matter arising from a hidden sector consisting of $N_{\rm sec}$ exact copies of the Standard Model is discussed. The particles from each sector interact with those from the other sectors by gravity and via the kinetic mixing interaction,
Foot, R.
core   +1 more source