Results 41 to 50 of about 123,988 (310)

Impact of elosulfase alfa in patients with morquio A syndrome who have limited ambulation: An open-label, phase 2 study. [PDF]

, 2017
Efficacy and safety of elosulfase alfa enzyme replacement therapy (ERT) were assessed in an open-label, phase 2, multi-national study in Morquio A patients aged ≥5 years unable to walk ≥30 meters in the 6-min walk test.
Berger, Kenneth I, Burton, Barbara K, Decker, Celeste, Geberhiwot, Tarekegn, Harmatz, Paul R, Hendriksz, Christian J, Jameson, Elisabeth, Jester, Andrea, Mengel, Eugen, Muschol, Nicole, Sisic, Zlatko, Treadwell, Marsha   +11 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Disturbances of skin microcirculation in lower extremities in diabetes mellitus:a pathophysiological phenomenon or an object for therapy?

Сахарный диабет, 2011
Functional microcirculatory abnormalities in the foot have been given much attention in the recent years for their potential pathogenetic role in thedevelopment of diabetic neuropathy and diabetic foot syndrome.
Vadim Borisovich Bregovsky, I A Karpova, E S Alekseeva   +2 more
doaj   +1 more source

Electrolytic lesions within central complex neuropils of the cockroach brain affect negotiation of barriers [PDF]

, 2010
Animals must negotiate obstacles in their path in order to successfully function within natural environments. These actions require transitions from walking to other behaviors, many of which are more involved than simple reflexes.
Harley, C. M., Ritzmann, R. E.
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Treatment timing and multidisciplinary approach in Apert syndrome [PDF]

, 2015
Apert syndrome is a rare congenital disorder characterized by craniosynostosis, midface hypoplasia and symmetric syndactyly of hands and feet. Abnormalities associated with Apert syndrome include premature fusion of coronal sutures system (coronal ...
CAPORLINGUA, ALESSANDRO, DI GIORGIO, GIANNI, FADDA, Maria Teresa, IERARDO, GAETANO, LADNIAK, BARBARA, RAPONI, INGRID, SILVESTRI, ALESSANDRO   +6 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Improvements in lower-limb muscle strength and foot pressure distribution with foot care in frail elderly adults: a randomized controlled trial from Japan

BMC Geriatrics, 2019
Background Abnormalities in the feet and toenails are common among the elderly and may increase the risk of falls. This study aimed to investigate the changes in toe-gap force, knee-gap force, foot pressure distribution, the ability to perform activities
Tomoko Yamashita, Kazuhiko Yamashita, Chugo Rinoie, Yoshimasa Takase, Mitsuru Sato, Kenji Yamada, Yoshiki Sawa   +6 more
doaj   +1 more source

Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice

Acta Neuropathologica Communications, 2023
Mild traumatic brain injury (mTBI) induced by low-intensity blast (LIB) is a serious health problem affecting military service members and veterans. Our previous reports using a single open-field LIB mouse model showed the absence of gross microscopic ...
Chao Li, Shanyan Chen, Heather R. Siedhoff, DeAna Grant, Pei Liu, Ashley Balderrama, Marcus Jackson, Amitai Zuckerman, C. Michael Greenlief, Firas Kobeissy, Kevin W. Wang, Ralph G. DePalma, Ibolja Cernak, Jiankun Cui, Zezong Gu   +14 more
doaj   +1 more source

Combination treatment of a deep diabetic toe ulcer with collagenase-santyl dressings and antibiotics: A case report

Journal of Holistic Integrative Pharmacy, 2023
A diabetic foot ulcer is defined as the ulceration of tissues brought on by trauma and some peripheral neurological abnormalities, primarily as a result of the bacterial infection. The infection of the toe's surrounding tissue is the primary cause of the
Salkapuram Sunil Kumar, Karthikeyan Elumalai, Srinivasan Sivannan, Sivaneswari Srinivasan, Santhana Krishnan Ramanujam, Binoy Varghese Cherian   +5 more
doaj   +1 more source